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دسته بندی:
مهندسی پزشکی - Biomedical Engineering
سال انتشار:
2013
عنوان انگلیسی مقاله:
Poly (3,4-ethylenedioxythiophene)/multiwall carbon nanotube composite coatings for improving the stability of microelectrodes in neural prostheses applications
ترجمه فارسی عنوان مقاله:
Poly (3,4-ethylenedioxythiophene)/multiwall carbon nanotube composite coatings for improving the stability of microelectrodes in neural prostheses applications
منبع:
sciencedirect - elsevier
نویسنده:
Haihan Zhou a , Xuan Cheng b , Li Rao b , Tao Li b , Yanwen Y. Duan
چکیده انگلیسی:
With the purpose of improving the stability of microelectrodes under continuous high charge density stimulation, which is required for neural prostheses applications such as visual prostheses, multiwall carbon nanotube (MWCNT)-doped poly(3,4-ethylenedioxythiophene) (PEDOT) composite films were coated onto a platinum microelectrode by electrochemical polymerization. Galvanostatically polymerized PEDOT/MWCNT films demonstrated superior characteristics compared to polystyrene sulfonate doping and potentiostatic polymerization, including a three-dimensional cone morphology and enhanced electrochemical performance (the safe charge injection limit reached 6.2 mC cm2 for cathodic-first pulses). Most important of all, the improved stability of the coatings has been revealed through stimulation for 96 h using 3.0 mC cm2 current pulses in bicarbonate- and phosphate-buffered saline solution. Cell assays revealed that PEDOT/MWCNT films could promote the adhesion and neurite outgrowth of rat pheochromocytoma cells. Finally, platinum wires coated with PEDOT/MWCNT films were implanted into rat cortex for 6 weeks for histological evaluation. Glial fibrillary acidic protein and neuronal nuclei staining revealed that the films elicit a lower tissue response compared to platinum implants. These results suggest that the galvanostatically polymerized PEDOT/MWCNT films can improve the stability of stimulation microelectrodes and that PEDOT/MWCNT is an excellent candidate material for electrode coating for neural prostheses applications. Keywords: Conducting polymers Carbon nanotubes Electrode–neuron interface Neural prostheses Microelectrode arrays
قیمت: رایگان
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