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دسته بندی:
داده کاوی - data mining
سال انتشار:
2015
عنوان انگلیسی مقاله:
Comedications alter drug-induced liver injury reporting frequency: Data mining in the WHO VigiBase
ترجمه فارسی عنوان مقاله:
Comedications alter drug-induced liver injury reporting frequency: Data mining in the WHO VigiBase
منبع:
Sciencedirect - Elsevier - REGULATORY TOXICOLOGY AND PHARMACOLOGY, 72 (2015) 481-490. doi:10.1016/j.yrtph.2015.05.004
نویسنده:
Ayako Suzuki a, Nancy A. Yuen b, Katarina Ilic c, Richard T. Miller d, Melinda J. Reese e, H. Roger Brown d, Jeffrey I. Ambroso d, J. Gregory Falls d, Christine M. Hunt
چکیده انگلیسی:
Polypharmacy is common, and may modify mechanisms of drug-induced liver injury. We examined the effect of these drug–drug interactions on liver safety reports of four drugs highly associated with hepa- totoxicity. In the WHO VigiBase™, liver event reports were examined for acetaminophen, isoniazid, val- proic acid, and amoxicillin/clavulanic acid. Then, we evaluated the liver event reporting frequency of these 4 drugs in the presence of co-reported medications. Each of the 4 primary drugs was reported as having more than 2000 liver events, and co-reported with more than 600 different medications. Overall, the effect of 2275 co-reported drugs (316 drug classes) on the reporting frequency was analyzed. Decreased liver event reporting frequency was associated with 245 drugs/122 drug classes, includinganti-TNFa, opioids, and folic acid. Increased liver event reporting frequency was associated with 170drugs/82 drug classes; in particular, halogenated hydrocarbons, carboxamides, and bile acid sequestrants.After adjusting for age, gender, and other co-reported drug classes, multiple co-reported drug classes were significantly associated with decreased/increased liver event reporting frequency in a drug-specific/unspecific manner. In conclusion, co-reported medications were associated with changes in the liver event reporting frequency of drugs commonly associated with hepatotoxicity, suggesting that comedications may modify drug hepatic safety.© 2015 Elsevier Inc. All rights reserved.
Keywords: Drug-induced liver injury | Hepatotoxicity | Concomitant medications | Spontaneous adverse event reporting | system | Quantitative signal detection | methods
قیمت: رایگان
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