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دسته بندی:
پزشکی 1 - medical
سال انتشار:
2017
عنوان انگلیسی مقاله:
Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia
ترجمه فارسی عنوان مقاله:
ارتباط بین معیارهای ارتباط اجتماعی، عامل سرطان مغز، نوروپاتی و خطر ابتلا به سکته مغزی و زوال عقل
منبع:
Sciencedirect - Elsevier - Alzheimers & Dementia: Translational Research & Clinical Interventions, 3 (2017) 229-237. doi:10.1016/j.trci.2017.03.001
نویسنده:
Joel Salinasa,b,c,d,*, Alexa Beiserb,e,f, Jayandra J. Himalib,e,f, Claudia L. Satizabalb,f, Hugo J. Apariciob,f, Galit Weinsteinb,g, Farrah J. Mateena, Lisa F. Berkmanc,d, Jonathan Rosanda,h, Sudha Seshadrib,f
چکیده انگلیسی:
Introduction: Mechanisms underlying social determinants of stroke and dementia are unclear and
brain-derived neurotrophic factor (BDNF) may contribute as a molecular link.
Methods: Using the Framingham Study, we examined social relationship measures as predictors of
higher serum BDNF level and cumulative incidence of stroke and dementia.
Results: Among 3294 participants, controlling for age and sex, isolation trended with lower BDNF
(odds ratio 5 0.69 [0.47–1.00]). Participants with more companionship had reduced risk for stroke
(hazard ratio [HR] 5 0.59 [0.41–0.83]) and dementia (HR 5 0.67 [0.49–0.92]). Greater emotional
support was associated with higher BDNF (odds ratio 5 1.27 [1.04–1.54]), reduced dementia risk
(HR 5 0.69 [0.51–0.94], and among smokers, reduced stroke risk (HR 5 0.23 [0.10–0.57]). Associ
ations persisted after additional adjustments. BDNF partly mediated the total effect between
emotional support and dementia risk.
Conclusions: Availability of social support appears to be associated with increased BDNF levels and, in
certain subsets, reduce risk of subsequent dementia and stroke, thus warranting study of these pathways to
understand their role in neuroprotection.
Keywords: Brain-derived neurotrophic factor | Social relationships | Social support | Social networks | Dementia | Stroke | Epidemiology | Cohort studies
قیمت: رایگان
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