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دسته بندی:
مدیریت برند - Brand management
سال انتشار:
2017
عنوان انگلیسی مقاله:
Comparison of the effectiveness of brand-name and generic antipsychotic drugs for treating patients with schizophrenia in Taiwan
ترجمه فارسی عنوان مقاله:
مقایسه اثربخشی نام تجاری داروهای ضد روان پریشی عمومی برای درمان بیماران مبتلا به اسکیزوفرنی در تایوان
منبع:
Sciencedirect - Elsevier - Schizophrenia Research xxx (2017) xxx–xxx
نویسنده:
Chih-Wei Hsu a, Sheng-Yu Lee b,c,d, Liang-Jen Wang d,f,c,e,⁎
چکیده انگلیسی:
The purpose of this nationwide population-based study is to compare the long-term effectiveness of brand-name
antipsychotics with generic antipsychotics for treating schizophrenia. We identified patients with schizophrenia
who were prescribed antipsychotics from a random sample of one million records from Taiwans National Health
Insurance database, observed between January 1, 2000 and December 31, 2012. Only those with no prior use of
antipsychotics for at least 180 days were included. We selected patients who were prescribed brand-name ris
peridone (N = 404), generic risperidone (N = 145), brand-name sulpiride (N = 334), or generic sulpiride (N
= 991). The effectiveness of the treatments researched in this study consisted of average daily doses, rates of
treatment discontinuation, augmentation therapy, and psychiatric hospitalization. We found that compared to
patients treated with generic risperidone, those treated with brand-name risperidone required lower daily
doses (2.14 mg vs. 2.61 mg). However, the two groups demonstrated similar rates of treatment discontinuation,
augmentation, and psychiatric hospitalization. On the other hand, in comparison with patients prescribed generic
sulpiride, those treated with brand-name sulpiride not only required lower daily doses (302.72 mg vs.
340.71 mg) but also had lower psychiatric admission rates (adjusted hazard ratio: 0.24, 95% confidence interval:
0.10–0.56). In conclusion, for both risperidone and sulpiride, higher daily doses of the respective generic drugs
were prescribed than with brand-name drugs in clinical settings. Furthermore, the brand-name sulpiride is
more effective at preventing patients from hospitalization than generic sulpiride. These findings can serve as
an important reference for clinical practices and healthcare economics for treating schizophrenic patients.
Keywords: Brand-name | Generic | Antipsychotics | Psychosis | Effectiveness | Cohort study
قیمت: رایگان
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