سال انتشار:

2019

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ترجمه فارسی عنوان مقاله:

نانوذرات طلای چند شاخه عامل دار با لوودوپا به عنوان نانوحامل های هدفمند مغزی

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عنوان انگلیسی مقاله:

L-DOPA functionalized, multi-branched gold nanoparticles as brain-targeted nano-vehicles

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منبع:

Sciencedirect - Elsevier - Nanomedicine: Nanotechnology, Biology, and Medicine 15 (2019) 1–11

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نویسنده:

Daniel A: Gonzalez-Carter, PhDa,b,⁎,1,2, Zhan Yuin Ong, PhDc,d,⁎⁎,2, Catriona M: McGilvery, PhDa, Iain E: Dunlop, DPhila, David T: Dexter, PhDb, Alexandra E: Porter, PhD

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چکیده انگلیسی:

The blood–brain barrier (BBB) is a protective endothelial barrier lining the brain microvasculature which prevents brain delivery of therapies against brain diseases. Hence, there is an urgent need to develop vehicles which efficiently penetrate the BBB to deliver therapies into the brain. The drug L-DOPA efficiently and specifically crosses the BBB via the large neutral amino acid transporter (LAT)-1 protein to enter the brain. Thus, we synthesized L-DOPA-functionalized multi-branched nanoflower-like gold nanoparticles (L-DOPA-AuNFs) using a seed-mediated method involving catechols as a direct reducing-cum-capping agent, and examined their ability to cross the BBB to act as brain-penetrating nanovehicles. We show that L-DOPA-AuNFs efficiently penetrate the BBB compared to similarly sized and shaped AuNFs functionalized with a non-targeting ligand. Furthermore, we show that L-DOPA-AuNFs are efficiently internalized by brain macrophages without inducing inflammation. These results demonstrate the application of L-DOPA-AuNFs as a non-inflammatory BBB-penetrating nanovehicle to efficiently deliver therapies into the brain.
Key words: Brain targeting | Blood–brain barrier | Gold nanoparticles | L-DOPA

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چکیده فارسی:

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حجم فایل: 0 کیلوبایت

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قیمت: 31000 تومان    24800 تومان (20 % تخفیف)

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توضیحات اضافی:

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