با سلام خدمت کاربران در صورتی که با خطای سیستم پرداخت بانکی مواجه شدید از طریق کارت به کارت (6037997535328901 بانک ملی ناصر خنجری ) مقاله خود را دریافت کنید (تا مشکل رفع گردد).
دسته بندی:
بهداشت و درمان - Healthcare
سال انتشار:
2018
عنوان انگلیسی مقاله:
The association between plasma big endothelin-1 levels at admission and long-term outcomes in patients with atrial fibrillation
ترجمه فارسی عنوان مقاله:
ارتباط بین سطوح بالایی از اندوتلین-1 پلاسما در پذیرش و نتایج درازمدت در بیماران مبتلا به فیبریلاسیون دهلیزی
منبع:
Sciencedirect - Elsevier - Atherosclerosis, 272 (2018) 1-7: doi:10:1016/j:atherosclerosis:2018:02:034
نویسنده:
Shuang Wu, Yan-min Yang*, Jun Zhu, Jia-meng Ren, Juan Wang, Han Zhang, Xing-hui Shao
چکیده انگلیسی:
Background and aims: The prognostic role of big endothelin-1 (ET-1) in atrial fibrillation (AF) is unclear.
We aimed to assess its predictive value in patients with AF.
Methods: A total of 716 AF patients were enrolled and divided into two groups based on the optimal cut
off value of big ET-1 in predicting all-cause mortality. The primary outcomes were all-cause mortality and
major adverse events (MAEs). Cox regression analysis and net reclassification improvement (NRI)
analysis were performed to assess the predictive value of big ET-1 on outcomes.
Results: With the optimal cut-off value of 0.55 pmol/L, 326 patients were classified into the high big ET-1
levels group. Cardiac dysfunction and left atrial dilation were factors related to high big ET-1 levels.
During a median follow-up of 3 years, patients with big ET-1 0.55 pmol/L had notably higher risk of all
cause death (44.8% vs. 11.5%, p < 0.001), MAEs (51.8% vs. 17.4%, p < 0.001), cardiovascular death, major
bleeding, and tended to have higher thromboembolic risk. After adjusting for confounding factors, high
big ET-1 level was an independent predictor of all-cause mortality (hazard ratio (HR) 2.11, 95% confidence
interval (CI) 1.46e3.05; p < 0.001), MAEs (HR 2.05, 95% CI 1.50e2.80; p ¼ 0.001), and cardiovascular
death (HR 2.44, 95% CI 1.52e3.93; p < 0.001). NRI analysis showed that big ET-1 allowed a significant
improvement of 0.32 in the accuracy of predicting the risk of both all-cause mortality and MAEs.
Conclusions: Elevated big ET-1 levels is an independent predictor of long-term all-cause mortality, MAEs,
and cardiovascular death in patients with AF.
قیمت: رایگان
توضیحات اضافی:
تعداد نظرات : 0