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دسته بندی:
سیستم های خبره - expert systems
سال انتشار:
2019
عنوان انگلیسی مقاله:
SeDeM expert system for directly compressed tablet formulation: A review and new perspectives
ترجمه فارسی عنوان مقاله:
سیستم خبره SeDeM برای فرمول بندی قرص مستقیما فشرده شده: مرور و دیدگاه های جدید
منبع:
Sciencedirect - Elsevier - Powder Technology 342 (2019) 517–527
نویسنده:
Shengyun Dai a, Bing Xu a,b,⁎, Guolin Shi a, Junwen Liua, Zhiqiang Zhang c, Xinyuan Shi a,b, Yanjiang Qiao a,b,⁎
چکیده انگلیسی:
The pharmaceutical tablet formulation design is a risky and challenging process since it largely depends on experience.
The fundamental reasons lie in the lack of understanding of powder properties and the interactions
between the active pharmaceutical ingredients and excipients. To compensate these shortness, the use of expert
system (ES) in the formulation development has gradually drawn attentions during the last two decades. The
SeDeM expert system is one such intelligent tool aiming at designing direct compression (DC) tablet. It gathers
almost all the frequently used physical parameters to fully characterize the compressibility of powdered substances.
Themathematical equations for selection of excipients reflect the state of art knowledge of DC tablet formulation.
In this paper, the detailed history, principles, applications and derived forms of the SeDeM expert
system were reviewed. Contributions of the SeDeM expert system to the manufacturing classification system
(MCS) were illustrated. A SeDeM database named iTCM was innovatively proposed. All in all, the functions
and application scopes of the originally developed SeDeM expert system have been continuously extended
and more improvement could be achieved in the future.
Keywords: SeDeM expert system | Tablet formulation | Direct compression | Quality by design | Database
قیمت: رایگان
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