دانلود مقاله انگلیسی رایگان:پروفایل های رفتاری عصبی Zebrafish تغییر یافته توسط acesulfame (ACE) در محدوده no observed effect concentrations (NOECs) - 2020
بلافاصله پس از پرداخت دانلود کنید 2
دانلود مقاله انگلیسی داده های بزرگ رایگان
  • Zebrafish neuro-behavioral profiles altered by acesulfame (ACE) within the range of “no observed effect concentrations (NOECs)” Zebrafish neuro-behavioral profiles altered by acesulfame (ACE) within the range of “no observed effect concentrations (NOECs)”
    Zebrafish neuro-behavioral profiles altered by acesulfame (ACE) within the range of “no observed effect concentrations (NOECs)”

    سال انتشار:

    2020


    عنوان انگلیسی مقاله:

    Zebrafish neuro-behavioral profiles altered by acesulfame (ACE) within the range of “no observed effect concentrations (NOECs)”


    ترجمه فارسی عنوان مقاله:

    پروفایل های رفتاری عصبی Zebrafish تغییر یافته توسط acesulfame (ACE) در محدوده "no observed effect concentrations (NOECs)"


    منبع:

    Sciencedirect - Elsevier - Chemosphere, 243 (2020) 125431: doi:10:1016/j:chemosphere:2019:125431


    نویسنده:

    Gaopan Dong 1, Xiang Li 1, Guangxi Han, Lupei Du, Minyong Li*


    چکیده انگلیسی:

    Recently, artificial sweeteners have received widespread attention as the emerging environmental pollutants, among which, acesulfame (ACE) is ubiquitously present and extremely persistent in the ecosystem. Although the environmental behavior of ACE has already been well studied, its chronic ecotoxicological effects on aquatic organisms are rarely reported. Thus, more researches should be performed to determine the concentration which exerted the observable toxicological effect. Herein, we examined neuro-behavioral effects of ACE at 1, 10 and 100 mg/L on adult zebrafish via performing the behavioral test batteries including light/dark preference test, novel tank diving test, novel object exploration test, social preference test and colour-enhanced CPP test. In addition, in order to fully phenotype the behavioral alteration induced by ACE, we applied the techniques deriving from behavioral phenomics to analyze and interpret the big data from a large number of behavioral variables. Furthermore, the alterations of neurotransmitter in brain were also assayed to confirm the behavioral results. We found that ACE within the concentration range of No Observed Effect Concentrations (NOECs) had remarkably altered the neuro-behavioral profiles: altered the preference for light/dark, reduced the exploration ability of zebrafish in the novel tank and novel object exploration test, affected the group preference of zebrafish, changed the colour preference, learning and memory ability of zebrafish and disturbed the quantitative patterns of neurotransmitter in brain. As a result, this research can offer a reference for readjusting the NOECs of ACE and assessing neurotoxicity of artificial sweeteners.
    Keywords: Acesulfame (ACE) | Neuro-behavior | No observed effect concentrations (NOECs)


    سطح: متوسط
    تعداد صفحات فایل pdf انگلیسی: 11
    حجم فایل: 3413 کیلوبایت

    قیمت: رایگان


    توضیحات اضافی:




اگر این مقاله را پسندیدید آن را در شبکه های اجتماعی به اشتراک بگذارید (برای به اشتراک گذاری بر روی ایکن های زیر کلیک کنید)

تعداد نظرات : 0

الزامی
الزامی
الزامی
rss مقالات ترجمه شده rss مقالات انگلیسی rss کتاب های انگلیسی rss مقالات آموزشی
logo-samandehi