دانلود مقاله انگلیسی رایگان:اثربخشی و ایمنی محصولات بتا گلوکان تجاری و خوراکی استنشاق: مرور سیستماتیک کارآزمایی کنترل شده تصادفی - 2020
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  • Efficacy and safety of oral and inhalation commercial beta-glucan products: Systematic review of randomized controlled trials Efficacy and safety of oral and inhalation commercial beta-glucan products: Systematic review of randomized controlled trials
    Efficacy and safety of oral and inhalation commercial beta-glucan products: Systematic review of randomized controlled trials

    سال انتشار:

    2020


    عنوان انگلیسی مقاله:

    Efficacy and safety of oral and inhalation commercial beta-glucan products: Systematic review of randomized controlled trials


    ترجمه فارسی عنوان مقاله:

    اثربخشی و ایمنی محصولات بتا گلوکان تجاری و خوراکی استنشاق: مرور سیستماتیک کارآزمایی کنترل شده تصادفی


    منبع:

    Sciencedirect - Elsevier - Clinical Nutrition, 39 (2020) 40-48: doi:10:1016/j:clnu:2019:01:003


    نویسنده:

    Nikolina Markovina a, Ines Banjari b, Viljemka Bucevic Popovic c, Antonia Jelicic Kadic d, Livia Puljak


    چکیده انگلیسی:

    Background & aims: Beta-glucans are advertised as biologically active compounds, with various health claims.We aimed to summarize results about efficacy and safety of commercial oral and inhalation betaglucan products on human health from randomized controlled trials (RCTs). Methods: We conducted systematic review of RCTs. We searched MEDLINE, CENTRAL and ClinicalTrials. gov. Any commercial product, any types of participants and any health-related outcomes were eligible. Two authors independently screened studies and extracted data. Cochrane risk of bias tool was used. This review did not have any extramural funding. Registration: PROSPERO record no. 42016043539. Results: We included 30 RCTs that were conducted on healthy or ill participants. Most of the trials reported beneficial effect of beta-glucan, but among the 105 different outcome domains and measures that were used, only three could be considered clinically relevant, while others were various biomarkers and surrogate outcomes such as complete blood count. Included studies on average had 33 participants per study arm, high or unclear risk of bias of at least one domain, and only half of them reported data for safety. More than half of trials that reported source of funding indicated commercial sponsorship from producers of beta-glucan. Only five RCTs reported trial registration. Conclusions: Commercial beta-glucan products were studied in a number of RCTs whose results can be considered only as preliminary, as they used small number of participants and surrogate outcomes. The quality of many studies was poor and further research and trials on bigger population should be performed before a final conclusion can be made.
    Keywords: Beta-glucan | Systematic review | Evidence | Randomized controlled trial | Research waste


    سطح: متوسط
    تعداد صفحات فایل pdf انگلیسی: 9
    حجم فایل: 287 کیلوبایت

    قیمت: رایگان


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