عنوان انگلیسی مقاله:
Establishing thresholds and effects of gender, age, and season for thyroglobulin and thyroid peroxidase antibodies by mining real-world big data
ترجمه فارسی عنوان مقاله:
تعیین آستانه ها و اثرات جنسیت ، سن و فصل آنتی بادی های تیروگلوبولین و تیروئید پراکسیداز با استخراج داده های بزرگ دنیای واقعی
Sciencedirect - Elsevier - Clinical Biochemistry, 74 (2019) 36-41: doi:10:1016/j:clinbiochem:2019:08:011
Chaochao Ma1, Dandan Li1, Yicong Yin1, Jie Wu, Xiuzhi Guo, Ruili Zhang, Yingying Hu, Yutong Zou, Wenzheng Li, Danchen Wang, Xinqi Cheng⁎, Ling Qiu⁎
Background: Thyroglobulin antibody (TG-Ab) and thyroid peroxidase antibody (TPO-Ab) are cornerstone biomarkers
for autoimmune thyroid diseases, and establishment of appropriate thresholds is crucial for physicians
to appropriately interpret test results. Therefore, we established the thresholds of TG-Ab and TPO-Ab in the
Chinese population through analysis of real-world big data, and explored the influence of age, gender, and
seasonal factors on their levels.
Methods: The data of 35,869 subjects downloaded from electronic health records were analyzed after filtering
based on exclusion criteria and outliers. The influence of each factor on antibody levels was analyzed by stratification.
Thresholds of TG-Ab and TPO-Ab were established through Clinical Laboratory Standards Institute
document C28-A3 and National Academy of Clinical Biochemistry (NACB) guidelines, respectively.
Results: There were significant differences according to gender after age stratification; the level of TG-Ab gradually
increased with age in females. There were significant differences in TG-Ab and TPO-Ab distributions with
respect to age after gender stratification. Moreover, differences were observed between seasons for TG-Ab and
TPO-Ab. The thresholds of TG-Ab and TPO-Ab were 107 [90% confidence interval (CI):101–115] IU/mL and 29
(90% CI: 28–30) IU/mL, respectively, using C28-A3 guidelines, but were 84 (90% l CI: 50–126) IU/mL and 29
(90% CI: 27–34) IU/mL, respectively, using NACB guidelines.
Conclusion: The levels of TG-Ab and TPO-Ab were significantly affected by gender, age, and season. The
thresholds for TG-Ab and TPO-Ab for the Chinese population were established by big data analysis.
Keywords: Thyroglobulin antibody | Thyroid peroxidase antibody | Threshold | Data mining