دانلود مقاله انگلیسی رایگان:تعیین آستانه ها و اثرات جنسیت ، سن و فصل آنتی بادی های تیروگلوبولین و تیروئید پراکسیداز با استخراج داده های بزرگ دنیای واقعی - 2019
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  • Establishing thresholds and effects of gender, age, and season for thyroglobulin and thyroid peroxidase antibodies by mining real-world big data Establishing thresholds and effects of gender, age, and season for thyroglobulin and thyroid peroxidase antibodies by mining real-world big data
    Establishing thresholds and effects of gender, age, and season for thyroglobulin and thyroid peroxidase antibodies by mining real-world big data

    سال انتشار:

    2019


    عنوان انگلیسی مقاله:

    Establishing thresholds and effects of gender, age, and season for thyroglobulin and thyroid peroxidase antibodies by mining real-world big data


    ترجمه فارسی عنوان مقاله:

    تعیین آستانه ها و اثرات جنسیت ، سن و فصل آنتی بادی های تیروگلوبولین و تیروئید پراکسیداز با استخراج داده های بزرگ دنیای واقعی


    منبع:

    Sciencedirect - Elsevier - Clinical Biochemistry, 74 (2019) 36-41: doi:10:1016/j:clinbiochem:2019:08:011


    نویسنده:

    Chaochao Ma1, Dandan Li1, Yicong Yin1, Jie Wu, Xiuzhi Guo, Ruili Zhang, Yingying Hu, Yutong Zou, Wenzheng Li, Danchen Wang, Xinqi Cheng⁎, Ling Qiu⁎


    چکیده انگلیسی:

    Background: Thyroglobulin antibody (TG-Ab) and thyroid peroxidase antibody (TPO-Ab) are cornerstone biomarkers for autoimmune thyroid diseases, and establishment of appropriate thresholds is crucial for physicians to appropriately interpret test results. Therefore, we established the thresholds of TG-Ab and TPO-Ab in the Chinese population through analysis of real-world big data, and explored the influence of age, gender, and seasonal factors on their levels. Methods: The data of 35,869 subjects downloaded from electronic health records were analyzed after filtering based on exclusion criteria and outliers. The influence of each factor on antibody levels was analyzed by stratification. Thresholds of TG-Ab and TPO-Ab were established through Clinical Laboratory Standards Institute document C28-A3 and National Academy of Clinical Biochemistry (NACB) guidelines, respectively. Results: There were significant differences according to gender after age stratification; the level of TG-Ab gradually increased with age in females. There were significant differences in TG-Ab and TPO-Ab distributions with respect to age after gender stratification. Moreover, differences were observed between seasons for TG-Ab and TPO-Ab. The thresholds of TG-Ab and TPO-Ab were 107 [90% confidence interval (CI):101–115] IU/mL and 29 (90% CI: 28–30) IU/mL, respectively, using C28-A3 guidelines, but were 84 (90% l CI: 50–126) IU/mL and 29 (90% CI: 27–34) IU/mL, respectively, using NACB guidelines. Conclusion: The levels of TG-Ab and TPO-Ab were significantly affected by gender, age, and season. The thresholds for TG-Ab and TPO-Ab for the Chinese population were established by big data analysis.
    Keywords: Thyroglobulin antibody | Thyroid peroxidase antibody | Threshold | Data mining


    سطح: متوسط
    تعداد صفحات فایل pdf انگلیسی: 6
    حجم فایل: 2487 کیلوبایت

    قیمت: رایگان


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