دانلود مقاله انگلیسی رایگان:The Vps52 subunit of the GARP and EARP complexes is a novel Arf6- interacting protein that negatively regulates neurite outgrowth of hippocampal neurons - 2020
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  • The Vps52 subunit of the GARP and EARP complexes is a novel Arf6- interacting protein that negatively regulates neurite outgrowth of hippocampal neurons The Vps52 subunit of the GARP and EARP complexes is a novel Arf6- interacting protein that negatively regulates neurite outgrowth of hippocampal neurons
    The Vps52 subunit of the GARP and EARP complexes is a novel Arf6- interacting protein that negatively regulates neurite outgrowth of hippocampal neurons

    سال انتشار:

    2020


    عنوان انگلیسی مقاله:

    The Vps52 subunit of the GARP and EARP complexes is a novel Arf6- interacting protein that negatively regulates neurite outgrowth of hippocampal neurons


    ترجمه فارسی عنوان مقاله:

    The Vps52 subunit of the GARP and EARP complexes is a novel Arf6- interacting protein that negatively regulates neurite outgrowth of hippocampal neurons


    منبع:

    Sciencedirect - Elsevier - Brain Research, 1745 (2020) 146905: doi:10:1016/j:brainres:2020:146905


    نویسنده:

    Kanta Ibuchi1, Masahiro Fukaya1, Tetsuro Shinohara, Yoshinobu Hara, Tomoko Shiroshima, Takeyuki Sugawara, Hiroyuki Sakagami


    چکیده انگلیسی:

    ADP ribosylation factor 6 (Arf6) is a small GTP-binding protein implicated in neuronal morphogenesis through endosomal trafficking and actin remodeling. In this study, we identified Vps52, a core subunit of the Golgiassociated retrograde protein (GARP) and endosome-associated recycling protein (EARP) complexes, as a novel Arf6-binding protein by yeast two-hybrid screening. Vps52 interacted specifically with GTP-bound Arf6 among the Arf family. Immunohistochemical analyses of hippocampal pyramidal cells revealed that fine punctate immunolabeling for Vps52 was distributed throughout neuronal compartments, most densely in the cell body and dendritic shafts, and was largely associated with trans-Golgi network and vesicular endomembranes. In cultured hippocampal neurons, knockdown of Vps52 increased total length of axons and dendrites; these phenotypes were completely restored by co-expression of shRNA-resistant full-length Vps52. However, co-expression of a Vps52 mutant lacking the ability to interact with Arf6 restored only the Vps52-knockdown phenotype of the dendritic length. The present findings suggest that Vps52 is a novel Arf6-interacting protein that regulates neurite outgrowth in hippocampal neurons.
    Keywords: Arf6 | Tethering factor | trans-Golgi network | Endosome | Neurite outgrowth | Hippocampus


    سطح: متوسط
    تعداد صفحات فایل pdf انگلیسی: 12
    حجم فایل: 4387 کیلوبایت

    قیمت: رایگان


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