عنوان انگلیسی مقاله:
Development of a chemometric-assisted spectrophotometric method for quantitative simultaneous determination of Amlodipine and Valsartan in commercial tablet
ترجمه فارسی عنوان مقاله:
توسعه یک روش اسپکتروفتومتری با کمک شیمیایی برای تعیین کمی همزمان آملودیپین و والرسارتان در قرص تجاری
Sciencedirect - Elsevier - Optik - International Journal for Light and Electron Optics, 218 (2020) 165110. doi:10.1016/j.ijleo.2020.165110
Atiyeh Darbandi, Mahmoud Reza Sohrabi*, Manouchehr Bahmaei
In this study, two drugs named Amlodipine (AML) and Valsartan (VAL) related to the high blood
pressure were simultaneously determined in synthetic mixtures and Valzomix tablet. For this
purpose, the chemometric-assisted spectrophotometric method was developed without any prepreparation.
Artificial intelligence techniques, including artificial neural network (ANN) and
least squares support vector machine (LS-SVM) as chemometrics procedures were proposed.
Feed-forward back-propagation neural network (FFBP-NN) with two different algorithms, containing
Levenberg–Marquardt (LM) and gradient descent with momentum and adaptive learning
rate backpropagation (GDX) was applied. To select the best model, several layers and neurons
were investigated. The results revealed that layer = 5 with 6 neurons and layer = 2 with 10
neurons had lower mean square error (MSE) (1.41 × 10−24, 1.16 × 10-23) for AML and VAL,
respectively. In the LS-SVM method, gamma (γ) and sigma (σ) parameters were optimized. γ and
σ were obtained 50, 30 and 40, 40 with the root mean square error (RMSE) of 0.4290 and 0.5598
for AML and VAL, respectively. Analysis of the pharmaceutical formulation was evaluated
through the chemometrics methods and high-performance liquid chromatography (HPLC) as a
reference technique. The obtained results were statistically compared with each other using the
one-way analysis of variance (ANOVA) test. There were no significant differences between them
and the proposed method was satisfactory for estimating the components of the Valzomix tablet.
Keywords: Spectrophotometry | Amlodipine | Valsartan | Artificial neural network | Least squares support vector machine