دانلود مقاله انگلیسی رایگان:اثرات عصبی کوتاه مدت Fumonisin B1 بر فعالیت عصبی در جوندگان - 2020
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  • Short-term neuronal effects of Fumonisin B1 on neuronal activity in rodents Short-term neuronal effects of Fumonisin B1 on neuronal activity in rodents
    Short-term neuronal effects of Fumonisin B1 on neuronal activity in rodents

    سال انتشار:

    2020


    عنوان انگلیسی مقاله:

    Short-term neuronal effects of Fumonisin B1 on neuronal activity in rodents


    ترجمه فارسی عنوان مقاله:

    اثرات عصبی کوتاه مدت Fumonisin B1 بر فعالیت عصبی در جوندگان


    منبع:

    Sciencedirect - Elsevier - Neurotoxicology, Journal Pre-proof. doi:10.1016/j.neuro.2020.06.007


    نویسنده:

    Veronika B´ odi (Investigation) (Visualization) (Writing - original draft) (Writing - review and editing), Vivien Csik´os (Investigation) (Visualization), Erika Anik´o R´ atkai (Investigation) (Visualization), Attila Sz˝ucs (Investigation) (Software) (Visualization), Attila T´oth (Investigation) (Visualization) (Writing - original draft) (Writing - review and editing), Katalin Sz´adeczky-KardossInvestigation, Visualization), A´ rpa´d Dobolyi (Conceptualization) (Supervision) (Methodology), Katalin Schlett (Conceptualization) (Supervision) (Methodology), Ildik ´o Vil ´ agi


    چکیده انگلیسی:

    Fumonisin B1 (FB1) is a mycotoxin produced by microscopic fungi (mostly Fusarium species), which may infect our major crops. The toxin inhibits the development of these plants and may also have harmful effects on animals and humans consuming the infected crops. FB1 inhibits sphingolipid biosynthesis which leads to altered membrane characteristics and consequently, altered cellular functions. There are some indications that the toxin has inhibitory effects on neuronal activity in case of repeated consumption, presumably due to sphingolipid depletion. However, according to new literature data, FB1 may have acute excitatory neural effects, too, via different mechanisms of action. Therefore, in the present study, we addressed the neuronal network effects of FB1 following acute treatment, using different electrophysiological techniques in vitro and in vivo. Acute treatments with FB1 (10-100 μM) were carried out on brain slices, tissue cultures and live animals. After direct treatment of samples, electrically evoked or spontaneous field potentials were examined in the hippocampus and the neocortex of rat brain slices and in hippocampal cell cultures. In the hippocampus, a short-term increase in the excitability of neuronal networks and individual cells was observed in response to FB1 treatment. In some cases, the initially enhanced excitation was reversed presumably due to overactivation of neuronal networks. Normal spontaneous activity was found to be stimulated in hippocampal cell cultures. Seizure susceptibility was not affected in the neocortex of brain slices. For the verification of the results caused by direct treatment, effects of systemic administration of FB1 (7.5 mg/kg, i.p.) were also examined. Evoked field potentials recorded in vivo from the somatosensory cortex and cell activation measured by the c-fos technique in hippocampus and somatosensory cortex were analyzed. However, the hippocampal and cortical stimulatory effect detected in vitro could not be demonstrated by these in vivo assays. Altogether, the toxin enhanced the basic excitability of neurons and neuronal networks after direct treatment but there were no effects on the given brain areas after systemic treatment in vivo. Based on the observed in vitro FB1 effects and the lack of data on the penetration of FB1 across the blood-brain barrier, we assume that in vivo consequences of FB1 administration can be more prominent in case of perturbed blood-brain barrier functions.
    Keywords: neurotoxicity | electrophysiology | c-Fos, mycotoxin | field potential | brain slice | tissue culture


    سطح: متوسط
    تعداد صفحات فایل pdf انگلیسی: 31
    حجم فایل: 3298 کیلوبایت

    قیمت: رایگان


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