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عنوان انگلیسی مقاله:
Within-animal comparisons of novelty and cocaine neuronal ensemble overlap in the nucleus accumbens and prefrontal cortex
ترجمه فارسی عنوان مقاله:
مقایسه بین حیوانات از تازگی و مجموعه عصبی عصبی کوکائین در هسته جمع شده و قشر جلوی مغز
Sciencedirect - Elsevier - Behavioural Brain Research, 379 (2020) 112275: doi:10:1016/j:bbr:2019:112275
Natalie N. Nawarawonga,b, Christopher M. Olsena,b,*
Novelty seeking is a personality trait associated with an increased vulnerability for substance abuse. In rodents,
elevated novelty seeking has been shown to be a predictor for elevated drug self-administration and compulsive
use. While previous studies have shown that both novelty and drugs of abuse have actions within similar mesocorticolimbic
regions, little is known as to whether the same neural ensembles are engaged by these two
stimuli. Using the TetTag mouse model and Fos immunohistochemistry, we measured neurons engaged by novelty
and acute cocaine exposure, respectively in the prefrontal cortex (PFC) and nucleus accumbens (NAc).
While there was no significant impact of novelty exposure on the size of the EGFP+ ensemble, we found that
cocaine engaged significantly more Fos+ neurons in the NAc, while stress increased the size of the Fos+ ensemble
in the PFC. Analysis of ensemble reactivation was specific to the emotional valence of the second stimuli.
We found that a greater proportion of the EGFP+ ensemble was reactivated in the groups that paired novelty
with a positive (cocaine) or neutral (saline) experience in the NAc, while the novelty/stress paired groups exhibited
significantly less ensemble overlap in the PFC. However, only in the NAc shell was this increase in
ensemble overlap specific to those exposed to both novelty and cocaine. This suggests that the NAc shell, but not
the NAc core or PFC, may play an important role in general reward processing by engaging a similar network of
Keywords: Novelty seeking | Stress | Cocaine | Psychostimulant | TetTag mouse model | Sex differences