عنوان انگلیسی مقاله:
A literature review and meta-analysis on the effects of ADHD medications on functional outcomes
ترجمه فارسی عنوان مقاله:
بررسی ادبیات و متاآنالیز در مورد تأثیر داروهای ADHD بر نتایج عملکردی
Sciencedirect - Elsevier - Journal of Psychiatric Research, 123 (2020) 21-30. doi:10.1016/j.jpsychires.2020.01.006
Heidi Bolanda, Maura DiSalvoa, Ronna Frieda, K. Yvonne Woodwortha, Timothy Wilensb, Stephen V. Faraonec, Joseph Biedermanb
Objective: To conduct a systematic review and meta-analysis of literature from large databases and registries to
assess the effects of ADHD medication on associated functional outcomes.
Study design: A literature search was performed in PubMed, PsycINFO, MEDLINE, and Web of Science for articles
published prior to January 2019. Sample size, age range, country of origin, medication type, number of functional
events and non-events, odds ratios and hazard ratios, and means and standard deviations were extracted.
Random-effects meta-analyses were conducted for 21 studies examining functional outcomes.
Results: 40 articles were included. The majority suggest a robust protective effect of ADHD medication treatment
on mood disorders, suicidality, criminality, substance use disorders, accidents and injuries, traumatic brain
injuries, motor vehicle crashes, and educational outcomes. Similarly, the meta-analyses demonstrated a protective
effect of medication treatment on academic outcomes, accidents and injuries, and mood disorders.
Conclusions: These findings suggest that ADHD medication treatments are associated with decreases in the risks
for a wide range of ADHD-associated functional outcomes supporting efforts aimed at early diagnosis and
treatment of individuals with ADHD.
Keywords: ADHD | Stimulants | Functional outcomes | Medication adherence