عنوان انگلیسی مقاله:
The synthetic cannabinoid 5F-MDMB-PICA: A case series
ترجمه فارسی عنوان مقاله:
کانابینوئید مصنوعی 5F-MDMB-PICA: یک سری مورد
Sciencedirect - Elsevier - Forensic Science International, 314 (2020) 110410. doi:10.1016/j.forsciint.2020.110410
J. Kleisa,*, T. Germerotta, S. Halterb,c, V. Hérouxa, J. Roehricha, C.S. Schwarza, C. Hessa
5F-MDMB-PICA has been detected in products sold on the internet as well as in biological samples since
2016. It is associated with serious adverse health and behavioral effects and even death.
Herein we report on twelve cases with proven 5F-MDMB-PICA consumption, including three fatalities,
four cases of driving under the influence of drugs and five other criminal acts. In these cases, 5F-MDMBPICA
was detected in postmortem blood or serum. Concentrations ranged from 0.1–16 ng/mL. In some
blood (serum) and urine samples, the hydrolysis metabolite of 5F-MDMB-PICA (M12) could also be
detected. In this case series, co-consumption with other drugs occurred in 9 of 12 cases, most commonly alcohol,
cannabis and other contemporary SCs. In five cases, 4F-MDMB-BINACA was also detected.
The described cases demonstrate various adverse effects that might be associated with 5F-MDMBPICA.
Observed physical adverse effects were mainly balance deficiencies and ocular effects such as
reddened conjunctivae, glassy eyes and delayed or unresponsive pupil light reactions. Observed mental
and behavioral effects were mainly changing moods, aggression, confusion, erratic behavior, mental
leaps, disorientation, slowed reaction, logorrhea and slurred speech.
Due to the fast changing market of synthetic cannabinoids, data on such new appearing substances are
basically scarce. Because of the limited number of studies on pharmacological properties of synthetic
cannabinoids, reports of findings in human samples along with corresponding case history descriptions
can be valuable for the interpretation of upcoming routine cases.
Keywords: 5F-MDMB-PICA | Intoxication | Synthetic cannabinoids | DUID | Post mortem | High resolution mass spectrometry