عنوان انگلیسی مقاله:
AI- modelling of molecular identification and feminization of wolbachia infected Aedes aegypti
ترجمه فارسی عنوان مقاله:
مدل سازی هوش مصنوعی شناسایی مولکولی و مونی سازی wolbachia infected Aedes aegypti
Sciencedirect - Elsevier - Progress in Biophysics and Molecular Biology, 150 (2020) 104-111. doi:10.1016/j.pbiomolbio.2019.07.001
Mehwish Iftikhar a, Sahrish Iftikhar b, Ayesha Sohail a, Sana Javed a, c, *
Background: The genetic control strategies of vector borne diseases includes the replacement of a vector
population by “disease-refractory” mosquitoes and the release of mosquitoes with a gene to control the
vectors reproduction rates. Wolbachia are common intracellular bacteria that are found in arthropods
and nematodes. Wolbachia infected male mosquitos have been used in different experimental trials
around the world to suppress the target population of Aedes aegypti and this genetic control strategy has
proved to be a promising alternative to other treatment strategies. Due to certain limitations, the successful
application of this strategy is still awaited.
Methods: Mathematical frame work for Wolbachia induced genetic control strategy has been developed
in this article. With the aid of Artificial Intelligence (AI) tools, accurate parametric values are depicted. For
the first time, the model is well synchronized with the experimental findings. The model is comprised of
the generalized varying coefficient and multiple mating rates between infected and uninfected compartments
of Aedes aegypti dengue to forecast the disease control.
Results: Two mathematical models are developed in this article to demonstrate different mating rates of
the genetic control strategy. The important parameters and time varying coefficients are well demonstrated
with the aid of numerical computations. The resulting thresholds and forecasting may prove to be
a useful tool for future experimental studies.
Conclusions: From our analysis, we have concluded that the genetic control strategy is a promising
technique and the role of Wolbachia infected male mosquitos, in genetic control strategies, can be better
interpreted in an inexpensive manner with the aid of a theoretical model.
Keywords: Dengue reproduction inhibition | Genetic control | Dynamical analysis | Kinetic modelling | Numerical simulations