عنوان انگلیسی مقاله:
Mechanism of anti-inflammatory effects of volatile compounds ofAi pian based on network pharmacology, in vivo animal experiments,and GC–MS
ترجمه فارسی عنوان مقاله:
مکانیسم اثرات ضد التهابی ترکیبات فرار بر اساس داروسازی شبکه ، آزمایشات داخل بدن حیوانات و GC-MS
Sciencedirect - Elsevier - Journal of Pharmaceutical and Biomedical Analysis, 186 (2020) 113287. doi:10.1016/j.jpba.2020.113287
Xulong Huanga, Zhen Mub, Feng Xua, Yuqing Liangc, Xiaosong Yanga, Juan Konga,Linlin Zhanga, Xiangpei Wanga,∗, Hongmei Wua
Ai pian (AP) is a well-known Miao national herb with resuscitative effects. However, pharmacologicaland clinical applications of AP are limited because its precise molecular mechanism remains unclear.This study was conducted to evaluate the anti-inflammatory activities of the volatile compounds of APin in vivo animal models and determine the molecular mechanism underlying the anti-inflammatoryeffects based on network pharmacology and molecular docking. We performed gas chromatography-mass spectrometric analysis of volatile compounds with chemometric methods, including hierarchicalclustering analysis and principal component analysis, to identify AP from different origins. Mouse modelsof xylene-induced ear edema were used to examine the in vivo anti-inflammatory activities of AP withcotton ball-granulation test. The mechanism of AP was determined by network pharmacology analysisand molecular docking. Significant differences in chemical constituents and percentage contents wereobserved among different habitats. We found that AP exerted potent anti-inflammatory effect, and thatmultiple targets and pathways were involved in this effect. These results provided a foundation for furthercomprehensive development and application of AP from Miao national herb.
Keywords:Ai pian | Gas chromatography-mass spectrometry | Volatile compound | Anti-inflammatory | Network pharmacology | Molecular docking