دانلود مقاله انگلیسی رایگان:آپولیپوپروتئین های AI و E همراه با آسیب عصبی آکسون ماده خاکستری در بیماری ام اس - 2020
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  • Apolipoproteins AI and E are associated with neuroaxonal injury to gray matter in multiple sclerosis Apolipoproteins AI and E are associated with neuroaxonal injury to gray matter in multiple sclerosis
    Apolipoproteins AI and E are associated with neuroaxonal injury to gray matter in multiple sclerosis

    سال انتشار:

    2020


    عنوان انگلیسی مقاله:

    Apolipoproteins AI and E are associated with neuroaxonal injury to gray matter in multiple sclerosis


    ترجمه فارسی عنوان مقاله:

    آپولیپوپروتئین های AI و E همراه با آسیب عصبی آکسون ماده خاکستری در بیماری ام اس


    منبع:

    Sciencedirect - Elsevier - Multiple Sclerosis and Related Disorders, 45 (2020) 102389: doi:10:1016/j:msard:2020:102389


    نویسنده:

    Mason McComba, Robert Parambia, Richard W. Browneb, Mary Lou Bodziakb, Dejan Jakimovskic, Niels Bergslandc,d, Aleksandra Maceskie, Bianca Weinstock-Guttmanf, Jens Kuhlee, Robert Zivadinovc,g, Murali Ramanathana,f


    چکیده انگلیسی:

    Purpose To investigate the associations between longitudinal changes in lipid biomarkers and serum neurofilament (sNfL) levels in multiple sclerosis (MS) neurodegeneration and disease progression. Methods 5-year prospective, longitudinal study included 75 relapsing-remitting MS (RR-MS) and 37 progressive- MS (P-MS) patients. sNfL, plasma total cholesterol (TC), high-density (HDL-C) and low-density (LDL-C) lipoprotein cholesterol, apolipoproteins (Apo), ApoA-I, Apo-II, ApoB, ApoC-II and ApoE were measured at baseline and 5-years. Annual percent changes in whole brain volume (PBVC), gray matter volume (PGMVC) and cortical volume (PCVC) were obtained from MRI at baseline and 5-years. Results sNfL levels at 5-year follow-up were associated with ApoE at follow-up (p = 0.014), age at follow-up, body mass index (p<0.001) and RR vs. P-MS status at follow-up. APOE4 allele was associated with greater sNfL levels at 5-years (p = 0.022) and pronounced in the P-MS group. PGMVC and PCVC were associated with percent changes in HDL-C (p = 0018 and p < 0.001, respectively) and ApoA-I (p = 0.0073 and p = 0.006). PGMVC and PCVC remained associated with percent change in HDL-C (p = 0.0024 and p < 0.001, respectively) after sNfL was included as a predictor. Conclusions HDL-C percent change is associated with decreased gray matter atrophy after adjusting for baseline sNfL.
    Keywords: Cholesterol | High density lipoprotein | Hdl | Apolipoproteins | Neurofilaments


    سطح: متوسط
    تعداد صفحات فایل pdf انگلیسی: 9
    حجم فایل: 527 کیلوبایت

    قیمت: رایگان


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