عنوان انگلیسی مقاله:
Apolipoproteins AI and E are associated with neuroaxonal injury to gray matter in multiple sclerosis
ترجمه فارسی عنوان مقاله:
آپولیپوپروتئین های AI و E همراه با آسیب عصبی آکسون ماده خاکستری در بیماری ام اس
Sciencedirect - Elsevier - Multiple Sclerosis and Related Disorders, 45 (2020) 102389: doi:10:1016/j:msard:2020:102389
Mason McComba, Robert Parambia, Richard W. Browneb, Mary Lou Bodziakb, Dejan Jakimovskic, Niels Bergslandc,d, Aleksandra Maceskie, Bianca Weinstock-Guttmanf, Jens Kuhlee, Robert Zivadinovc,g, Murali Ramanathana,f
Purpose To investigate the associations between longitudinal changes in lipid biomarkers and serum neurofilament
(sNfL) levels in multiple sclerosis (MS) neurodegeneration and disease progression.
Methods 5-year prospective, longitudinal study included 75 relapsing-remitting MS (RR-MS) and 37 progressive-
MS (P-MS) patients. sNfL, plasma total cholesterol (TC), high-density (HDL-C) and low-density (LDL-C)
lipoprotein cholesterol, apolipoproteins (Apo), ApoA-I, Apo-II, ApoB, ApoC-II and ApoE were measured at
baseline and 5-years. Annual percent changes in whole brain volume (PBVC), gray matter volume (PGMVC) and
cortical volume (PCVC) were obtained from MRI at baseline and 5-years.
Results sNfL levels at 5-year follow-up were associated with ApoE at follow-up (p = 0.014), age at follow-up,
body mass index (p<0.001) and RR vs. P-MS status at follow-up. APOE4 allele was associated with greater sNfL
levels at 5-years (p = 0.022) and pronounced in the P-MS group. PGMVC and PCVC were associated with
percent changes in HDL-C (p = 0018 and p < 0.001, respectively) and ApoA-I (p = 0.0073 and p = 0.006).
PGMVC and PCVC remained associated with percent change in HDL-C (p = 0.0024 and p < 0.001, respectively)
after sNfL was included as a predictor.
Conclusions HDL-C percent change is associated with decreased gray matter atrophy after adjusting for
Keywords: Cholesterol | High density lipoprotein | Hdl | Apolipoproteins | Neurofilaments