دانلود مقاله انگلیسی رایگان:ارزیابی سمیت عصبی کاربامات متومیل در Caenorhabditis elegans با رویکرد چند سطحی - 2021
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  • Assessing the neurotoxicity of the carbamate methomyl in Caenorhabditis elegans with a multi-level approach Assessing the neurotoxicity of the carbamate methomyl in Caenorhabditis elegans with a multi-level approach
    Assessing the neurotoxicity of the carbamate methomyl in Caenorhabditis elegans with a multi-level approach

    سال انتشار:

    2021


    عنوان انگلیسی مقاله:

    Assessing the neurotoxicity of the carbamate methomyl in Caenorhabditis elegans with a multi-level approach


    ترجمه فارسی عنوان مقاله:

    ارزیابی سمیت عصبی کاربامات متومیل در Caenorhabditis elegans با رویکرد چند سطحی


    منبع:

    Sciencedirect - Elsevier - Toxicology, 451 (2021) 152684: doi:10:1016/j:tox:2021:152684


    نویسنده:

    L. Queirós


    چکیده انگلیسی:

    The neurotoxicity and developmental effects of a widely applied insecticide (methomyl) was investigated by amulti-level approach (behavior and biometry, biochemical alterations and neurodegeneration) in Caenorhabditis elegans upon a short-term exposure (1 h) and a post-exposure period (48 h). The 1-h exposure to sub-lethalconcentrations of methomyl (lower than 0.320 g L—1; i.e. below the estimated LC10) triggered significant changes on motor behavior and development impairment. The type of movement was significantly altered in methomyl-exposed worms, as well as biometric parameters (worms frequently idle and moving more backwards than controls; small body area, length and wavelength). These effects were followed by an increase of acetyl- choline levels. Interestingly, after the 48-h recovery period, movement of previously exposed worms was similar to controls, and a concentration-dependent reversion of biometric endpoints was recorded, pointing out the transient action of the carbamate in line with an apparent absence of cholinergic neurons damage. This study provided new insight on the neurotoxicity of methomyl by showing that effects on movement and development were transient, and apparently did not result in neurodegeneration in cholinergic neurons. Moreover, these findings reinforced the advantages of using C. elegans in a multi-level approach for pesticide effects assessment.
    Keywords: Caenorhabditis elegans | Methomyl | Behavior | Acetylcholine | Neurodegeneration


    سطح: متوسط
    تعداد صفحات فایل pdf انگلیسی: 10
    حجم فایل: 3540 کیلوبایت

    قیمت: رایگان


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