عنوان انگلیسی مقاله:
Automated solubility screening platform using computer vision
ترجمه فارسی عنوان مقاله:
بستر غربالگری حلالیت خودکار با استفاده از بینایی ماشین
Sciencedirect - Elsevier - ISCIENCE, 24 (2021) 102176: doi:10:1016/j:isci:2021:102176
Solubility screening is an essential, routine process that is often labor intensive.
Robotic platforms have been developed to automate some aspects of the manual
labor involved. However, many of the existing systems rely on traditional analytic
techniques such as high-performance liquid chromatography, which require precalibration for each compound and can be resource consuming. In addition, automation is not typically end-to-end, requiring user intervention to move vials,
establish analytical methods for each compound and interpret the raw data.
We developed a closed-loop, flexible robotic system with integrated solid and
liquid dosing capabilities that relies on computer vision and iterative feedback
to successfully measure caffeine solubility in multiple solvents. After initial
researcher input (<2 min), the system ran autonomously, screening five different
solvent systems (20-80 min each). The resulting solubility values matched those
obtained using traditional manual techniques.