عنوان انگلیسی مقاله:
Sustainable chitosan-based electrical responsive scaffolds for tissue engineering applications
ترجمه فارسی عنوان مقاله:
داربست های پاسخگو الکتریکی مبتنی بر کیتوزان پایدار برای کاربردهای مهندسی بافت
ScienceDirect- Elsevier- Sustainable Materials and Technologies, 28 (2021) e00260: doi:10:1016/j:susmat:2021:e00260
Electroconductive biomaterials have potential in the regeneration of electrically active biological tissues (neural,
orthopedic, cardiac). The aim of this study was to develop an electroconductive scaffold using natural and/or
sustainable materials. A composite scaffold made of chitosan, a compound of natural origin, and with incorporated with graphitic carbon obtained from cork (natural and sustainable source) as an electroconductive filler,
was prepared. Chitosan (Ch) scaffolds with different concentration of pyrolyzed cork (PC) were prepared and
fully characterized. An electroconductivity of 5.5 × 10−5 S/cm, i.e. in the range of cardiac tissues, was obtained.
FTIR and XPS analysis did not show the presence of chemical bonds between the two components. Despite
this, the composite scaffold showed higher thermal stability; moreover, their mechanical strength was significantly higher than for the pure chitosan. The biocompatibility of Ch-PC composite scaffolds has been verified
by SH-SY5Y neuroblastoma cell viability assay. This study shows that a sustainable composite made with chitosan
and an innovative electroconductive filler has potential application in tissue engineering.
Keywords: Conductive polymers | Chitosan | Tissue engineering | Graphitic carbon | Natural sources