عنوان انگلیسی مقاله:
How does traditional knowledge of Cassiae semen shed light on weight management? – A classical and modern literature review
ترجمه فارسی عنوان مقاله:
دانش سنتی منی فلوس چگونه مدیریت وزن را روشن می کند؟ - بررسی ادبیات کلاسیک و مدرن
ScienceDirect- Elsevier- Journal of Ethnopharmacology, 268 (2021) 113572: doi:10:1016/j:jep:2020:113572
Ethnopharmacological relevance: The seed of Senna obtusifolia (L.) H. S. Irwin & Barneby (Cassiae semen, CS) also
known as Jue ming zi in China, has been traditionally used for weight management by purging the liver and
improving the liver functions to support digestion. In the past decades, it has been used for hepatoprotection and
treatment of overweight and other metabolic disorders such as hyperlipidaemia and diabetes.
Aim of the review: This review aimed at providing comprehensive information on the traditional usages, phar-
macology, phytochemistry and toxicology of CS and critically exploring its potential usage for clinical weight
management from both traditional and modern application perspectives.
Materials and methods: In order to fully understand the properties, actions and indications of CS, two sets of
Chinese classical texts were searched, namely: Zhong Hua Yi Dian (Encyclopedia of Traditional Chinese Medi-
cine) and Zhong Guo Ben Cao Quan Shu (Complete Collection of Traditional Texts on Chinese Materia Medica).
The purpose of studying these classical texts was to determine the traditional use of CS in weight management.
Comprehensive searches were also performed on seven databases for publications on original randomised clinical
trials (RCT), in vivo, in vitro or in silico studies related to pharmacological effects of CS. Detailed information
about the phytochemistry of CS was collected from books, encyclopedia, online databases and journal literature.
Findings: In classical literature review, 89 classic texts provided information of properties, actions and indications
of CS. In modern literature review, 44 studies were included for analysis, including 5 RCTs, 7 in vivo studies, 14 in
vitro studies, 2 in silico studies and 16 studies of mixed types. Chinese classic literature has provided traditional
evidence of the usage of CS for weight management. Contemporary studies have revealed that CS has weight loss
effects and possesses some other pharmacological activities supporting weight management. Some chemical
compounds of CS have been hypothesised to have a direct or indirect contribution to weight control.
Conclusions: The relationships between chemical compounds and the corresponding weight-loss target proteins
are not fully understood. Therefore, CS constituents should be further explored for the development of novel
therapeutic or preventive agents for the treatment of overweight and obesity.
keywords: طب سنتی چینی | چاقی | اضافه وزن | ملین | لیپیدها | Traditional Chinese medicine | Senna obtusifolia | Cassia obtusifolia | Cassiae semen | Obesity | Overweight | Laxative | Lipids