عنوان انگلیسی مقاله:
Cancer patient knowledge about and behavioral intentions after germline genome sequencing
ترجمه فارسی عنوان مقاله:
دانش بیمار سرطانی در مورد و مقاصد رفتاری پس از تعیین توالی ژنوم ژرملاین
ScienceDirect- Elsevier- Patient Education and Counseling,Corrected proof,doi:10:1016/j:pec:2021:07:004
Christine E. Napier
Objectives: Germline genome sequencing (GS) is becoming mainstream in cancer diagnosis and risk
management. Identifying knowledge gaps and determinants of health behavior change intentions will
enable effective targeting of educational and management strategies to translate genomic findings into
improved cancer outcomes.
Methods: Probands diagnosed with cancer of likely genetic origin that consented to but not yet undergone
GS, and their biological relatives, completed a cross-sectional questionnaire assessing GS knowledge and
hypothetical intention to change behaviors.
Results: Probands (n = 348; 57% university educated) and relatives (n = 213; 38% university educated) had
moderate GS knowledge levels, with greater knowledge associated with higher education. Both populations
reported high behavioral change intentions, significantly associated with being female (p = 0.01) and greater
perceived importance of GS (p < 0.001), and for probands: being from English-speaking households
(p = 0.003), higher socio-economic status (p = 0.01) and greater self-efficacy (p = 0.02).
Conclusions: Increasing GS knowledge will enable realistic participant expectations surrounding germline
GS. Actual behavior change should be monitored to determine whether increased cancer risk knowledge
results in altered cancer-related behavior and ultimately, cancer outcomes.
Practice implications: Educational resources should target specific populations to ensure informed decision-
making and expectation management. Support tools facilitating and maintaining behavioral change may be
needed to achieve improved cancer patient outcomes.
© 2021 Published by Elsevier B.V.
keywords: توالی ژنوم | سرطان | دانش | قصد رفتار | همبستگی | Genome sequencing | Cancer | Knowledge | Behavior intention | Correlates