عنوان انگلیسی مقاله:
Evaluation of six commercial SARS-CoV-2 rapid antigen tests in nasopharyngeal swabs: Better knowledge for better patient management?
ترجمه فارسی عنوان مقاله:
ارزیابی شش تست آنتی ژن سریع SARS-COV-2 در سواب های نازوفارنکس: دانش بهتر برای مدیریت بهتر بیمار؟
ScienceDirect- Elsevier- Journal of Clinical Virology, 143 (2021) 104947: doi:10:1016/j:jcv:2021:104947
Robust antigen point-of-care SARS-CoV-2 tests have been proposed as an efficient tool to address the COVID-19
pandemic. This requirement was raised after acknowledging the constraints that are brought by molecular
biology. However, worldwide markets have been flooded with cheap and potentially underperforming lateral
flow assays. Herein we retrospectively compared the overall performance of five qualitative rapid antigen SARS-
CoV-2 assays and one quantitative automated test on 239 clinical swabs. While the overall sensitivity and
specificity are relatively similar for all tests, concordance with molecular based methods varies, ranging from
75,7% to 83,3% among evaluated tests. Sensitivity is greatly improved when considering patients with higher
viral excretion (Ct≤33), proving that antigen tests accurately distinguish infectious patients from viral shedding.
These results should be taken into consideration by clinicians involved in patient triage and management, as well
as by national authorities in public health strategies and for mass campaign approaches.
keywords: SARS-DONE-2 | تست های آنتی ژن سریع | rt-pcr | کووید -19 | SARS-CoV-2 | Rapid antigen tests | RT-PCR | COVID-19