بینایی ماشین - Machine vision
عنوان انگلیسی مقاله:
Disintegration testing augmented by computer Vision technology
ترجمه فارسی عنوان مقاله:
آزمایش تجزیه با فناوری Vision کامپیوتری تقویت شده است
ScienceDirect- Elsevier- International Journal of Pharmaceutics, 619 (2022) 121668: doi:10:1016/j:ijpharm:2022:121668
Oral solid dosage forms, specifically immediate release tablets, are prevalent in the pharmaceutical industry.
Disintegration testing is often the first step of commercialization and large-scale production of these dosage
forms. Current disintegration testing in the pharmaceutical industry, according to United States Pharmacopeia
(USP) chapter 〈701〉, only gives information about the duration of the tablet disintegration process. This infor-
mation is subjective, variable, and prone to human error due to manual or physical data collection methods via
the human eye or contact disks. To lessen the data integrity risk associated with this process, efforts have been
made to automate the analysis of the disintegration process using digital lens and other imaging technologies.
This would provide a non-invasive method to quantitatively determine disintegration time through computer
algorithms. The main challenges associated with developing such a system involve visualization of tablet pieces
through cloudy and turbid liquid. The Computer Vision for Disintegration (CVD) system has been developed to
be used along with traditional pharmaceutical disintegration testing devices to monitor tablet pieces and
distinguish them from the surrounding liquid. The software written for CVD utilizes data captured by cameras or
other lenses then uses mobile SSD and CNN, with an OpenCV and FRCNN machine learning model, to analyze
and interpret the data. This technology is capable of consistently identifying tablets with ≥ 99.6% accuracy. Not
only is the data produced by CVD more reliable, but it opens the possibility of a deeper understanding of
disintegration rates and mechanisms in addition to duration.
keywords: از هم پاشیدگی | اشکال خوراکی جامد | تست تجزیه | یادگیری ماشین | شبکه های عصبی | Disintegration | Oral Solid Dosage Forms | Disintegration Test | Machine Learning | Neural Networks
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