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1 |
Biochanin A: A novel bioactive multifunctional compound from nature
Biochanin A: رویکرد ترکیب چند منظوره زیست فعال طبیعت-2020 Natural products (NPs) will continue to serve humans asmatchless source of novel drug leads and an inspiration
for the synthesis of non-natural drugs. As our scientific understanding of ‘nature’ is rapidly expanding, itwould be
worthwhile to illuminate the pharmacological distinctions of NPs to the scientific community and the public. Flavonoids
have long fascinated scientists with their remarkable structural diversity as well as biological functions.
Consequently, this review aims to shed light on the sources and pharmacological significance of a dietary isoflavone,
biochanin A, which has been recently emerged as a multitargeted and multifunctional guardian of human
health. Biochanin A possesses anti-inflammatory, anticancer, neuroprotective, antioxidant, anti-microbial, and
hepatoprotective properties. It combats cancer development by inducing apoptosis, inhibition of metastasis
and arresting cell cycle via targeting several deregulated signaling pathways of cancer. It fights inflammation
by blocking the expression and activity of pro-inflammatory cytokines via modulation of NF-κB and MAPKs.
Biochanin A acts as a neuroprotective agent by inhibiting microglial activation and apoptosis of neurons. As biochanin A has potential to modulate several biological networks, thus, it can be anticipated that this therapeutically
potent compound might serve as a novel lead for drug development in the near future. Keywords: Biochanin A | Isoflavone | Anticancer | Anti-inflammatory | Antioxidant | Neuroprotective | Anti-microbial |
مقاله انگلیسی |
2 |
Mechanism of anti-inflammatory effects of volatile compounds ofAi pian based on network pharmacology, in vivo animal experiments,and GC–MS
مکانیسم اثرات ضد التهابی ترکیبات فرار بر اساس داروسازی شبکه ، آزمایشات داخل بدن حیوانات و GC-MS-2020 Ai pian (AP) is a well-known Miao national herb with resuscitative effects. However, pharmacologicaland clinical applications of AP are limited because its precise molecular mechanism remains unclear.This study was conducted to evaluate the anti-inflammatory activities of the volatile compounds of APin in vivo animal models and determine the molecular mechanism underlying the anti-inflammatoryeffects based on network pharmacology and molecular docking. We performed gas chromatography-mass spectrometric analysis of volatile compounds with chemometric methods, including hierarchicalclustering analysis and principal component analysis, to identify AP from different origins. Mouse modelsof xylene-induced ear edema were used to examine the in vivo anti-inflammatory activities of AP withcotton ball-granulation test. The mechanism of AP was determined by network pharmacology analysisand molecular docking. Significant differences in chemical constituents and percentage contents wereobserved among different habitats. We found that AP exerted potent anti-inflammatory effect, and thatmultiple targets and pathways were involved in this effect. These results provided a foundation for furthercomprehensive development and application of AP from Miao national herb. Keywords:Ai pian | Gas chromatography-mass spectrometry | Volatile compound | Anti-inflammatory | Network pharmacology | Molecular docking |
مقاله انگلیسی |
3 |
Anti-inflammatory (AI) and crystalline hardness characterisations of 4- (4-chlorophenyl)-7,7-dimethyl-7,8-dihydro-4h-1-benzopyran-2,5 (3h,6h)-dione-(CPDMDHHBPHHD) – Comparative analysis of macro and nano scales crystals
خصوصیات ضد التهابی (AI) و سختی کریستالی 4- (4-کلروفنیل) -7،7-دی متیل-7،8-دی هیدرو-4 ساعت-1-بنزوپیران-2،5 (3 ساعت ، 6 ساعت) -دیون- (CPDMDHHBPHHD) ) - تحلیل مقایسه ای کریستال های مقیاس ماکرو و نانو-2020 CPDMDHHBPHHD nano crystals are having colossal opto-electronic application, stage coordinating,
recurrence coordinating and power transmission and different utilities. Full scale crystals have least
applications by esteem contrasted with nano type of CPDMDHHBPHHD arranged by processing strategy.
The nano type of CPDMDHHBPHHD crystals are of 228 nm, to 16 nm individually, the XRD information
uncovers the full scale crystals are having the equation C17H17ClO3 are of a = 11.9005 Å, b = 5.7971 Å,
c = 22.608 Å, b = 93.97, monoclinic with space group P21/n, the large scale level NLO is 1.25 occasions
than that of standard KDP. Here both the large scale and nano precious stones are experienced with
anti-inflammatory activity and nano structure very appropriate for medicate dependent on the qualities.
Large scale crystals with anti-inflammatory activity have hardness concentrates as well and brought
about hard class of materials. The sample is having Anti diabetic character also and good in electronic filter
utilities too for the societal utility by electronic and by bio and pharma applications.
2020 Elsevier Ltd. All rights reserved.
Selection and peer-review under responsibility of the scientific committee of the International Conference
on Nanotechnology: Ideas, Innovation and Industries. Keywords: CPDMDHHBPHHD | Nano crystals | Anti-inflammatory | Hardness | Stiffness | Brittleness | Macro level |
مقاله انگلیسی |
4 |
Deficiency of anti-inflammatory cytokine IL-4 leads to neural hyperexcitability and aggravates cerebral ischemia–reperfusion injury
کمبود سیتوکین ضد التهاب IL-4 منجر به فشار بیش از حد عصبی شده و آسیب به ایسکمی مغزی - مجدد جریان خون را تشدید می کند.-2020 Systematic administration of anti-inflammatory cytokine interleukin 4 (IL-4) has been
shown to improve recovery after cerebral ischemic stroke. However, whether IL-4 affects
neuronal excitability and how IL-4 improves ischemic injury remain largely unknown. Here we
report the neuroprotective role of endogenous IL-4 in focal cerebral ischemia–reperfusion (I/R)
injury. In multi-electrode array (MEA) recordings, IL-4 reduces spontaneous firings and network
activities of mouse primary cortical neurons. IL-4 mRNA and protein expressions are
upregulated after I/R injury. Genetic deletion of Il-4 gene aggravates I/R injury in vivo and
exacerbates oxygen-glucose deprivation (OGD) injury in cortical neurons. Conversely,
supplemental IL-4 protects Il-4–/– cortical neurons against OGD injury. Mechanistically, cortical
pyramidal and stellate neurons common for ischemic penumbra after I/R injury exhibit intrinsic
hyperexcitability and enhanced excitatory synaptic transmissions in Il-4–/– mice. Furthermore, upregulation of Nav1.1 channel, and downregulations of KCa3.1 channel and α6 subunit of GABAA receptors are detected in the cortical tissues and primary cortical neurons from Il-4–/–
mice. Taken together, our findings demonstrate that IL-4 deficiency results in neural
hhoottppaappeerr..nneett hyperexcitability and aggravates I/R injury, thus activation of IL-4 signaling may protect the
brain against the development of permanent damage and help recover from ischemic injury after
stroke. KEY WORDS Anoxic depolarization | IL-4 | Ischemia–reperfusion injury | Neuronal excitability | Synaptic transmissions |
مقاله انگلیسی |
5 |
Development of Machine Learning Algorithms for Prediction of Sustained Postoperative Opioid Prescriptions After Total Hip Arthroplasty
توسعه الگوریتم های یادگیری ماشین برای پیش بینی نسخه های افیونی پس از عمل پایدار پس از آرتروپلاستی کامل باسن-2019 Background: Postoperative recovery after total hip arthroplasty (THA) can lead to the development of
prolonged opioid use but there are few tools for predicting this adverse outcome. The purpose of this
study is to develop machine learning algorithms for preoperative prediction of prolonged opioid prescriptions
after THA.
Methods: A retrospective review of electronic health records was conducted at 2 academic medical
centers and 3 community hospitals to identify adult patients who underwent THA for osteoarthritis
between January 1, 2000 and August 1, 2018. Prolonged postoperative opioid prescriptions were defined
as continuous opioid prescriptions after surgery to at least 90 days after surgery. Five machine learning
algorithms were developed to predict this outcome and were assessed by discrimination, calibration, and
decision curve analysis.
Results: Overall, 5507 patients underwent THA, of which 345 (6.3%) had prolonged postoperative opioid
prescriptions. The factors determined for prediction of prolonged postoperative opioid prescriptions
were age, duration of opioid exposure, preoperative hemoglobin, and preoperative medications (antidepressants,
benzodiazepines, nonsteroidal anti-inflammatory drugs, and beta-2-agonists). The elasticnet
penalized logistic regression model achieved the best performance across discrimination
(c-statistic ¼ 0.77), calibration, and decision curve analysis. This model was incorporated into a digital
application able to provide both predictions and explanations (available at https://sorg-apps.shinyapps.
io/thaopioid/).
Conclusion: If externally validated in independent populations, the algorithms developed in this study
could improve preoperative screening and support for THA patients at high risk for prolonged postoperative
opioid prescriptions. Early identification and intervention in high-risk cases may mitigate the
long-term adverse consequence of opioid dependence.
Level of Evidence: III. Keywords: arthroplasty | machine learning | opioid use | orthopedic surgery | prediction | total hip arthroplasty |
مقاله انگلیسی |
6 |
Association of hyperglycemic crisis with an increased risk of end-stage renal disease: A nationwide population-based cohort study
انجمن بحران هیپرگلیسمی با افزایش خطر ابتلا به بیماری کلیوی در مرحله پایانی: مطالعات کوهورت مبتنی بر جمعیت در سراسر کشور-2018 Background: A hyperglycemic crisis episode (HCE) is associated with poor management of
diabetes, which is a risk factor for end-stage renal disease (ESRD); however, the association
between an HCE and ESRD has not been clarified. We conducted a nationwide population
based cohort study with the purpose of delineating this issue.
Methods: We identified 9208 diabetic patients with an HCE and an identical number of dia
betic patients with matched age, sex, and index date without an HCE between 2000 and
2002. A comparison of the risk of ESRD between the diabetic patients with and without
an HCE was achieved by a follow-up until 2014.
Results: A Cox proportional hazard regression analysis showed that the diabetic patients
with an HCE were at a higher risk of ESRD than those without an HCE (the adjusted hazard
ratio [AHR]: 1.47; 95% confidence interval [CI]: 1.34–1.62) by adjusting for renal disease,
hypertension, hyperlipidemia, coronary artery disease, hyperuricemia, anemia, chronic
obstructive pulmonary disease, liver disease, malignancy, connective tissue disease, non
steroid anti-inflammatory drug use, and monthly income. The increased risk of ESRD
was more prominent in the age subgroup of 15–25 years (AHR: 4.91; 95% CI: 1.92–12.56);
25–35 years (AHR: 2.42; 95% CI: 1.51–3.86); 35–45 years (AHR: 3.01; 95% CI: 2.21–4.09); and
45–55 years (AHR: 1.75; 95% CI: 1.41–2.19).
Conclusions: An HCE was associated with an increased risk of ESRD, especially in the
younger diabetic patients (15–55 years). A close follow-up for the control of diabetes and
for monitoring renal function is proposed.
Keywords: Diabetes ، End-stage renal disease ، Hyperglycemic crisis |
مقاله انگلیسی |
7 |
Predictors of venous thromboembolism recurrence and the bleeding events identified using a Japanese healthcare database
پیش بینی عود ترومبوآمبولی وریدی و حوادث خونریزی مشخص با استفاده از یک پایگاه داده های بهداشتی ژاپنی-2017 Background: Treatment to prevent the recurrence of venous thromboembolism (VTE) and prevent
bleeding events should be given to patients with VTE in an appropriate balance in relation to relevant
predictors. We elucidated the current medical care in a real world setting and quantified predictors using
a Japanese healthcare database.
Methods: The study included 3578 patients who were diagnosed with VTE between April 2008 and
September 2013 at a Japanese acute-care hospital and included in the hospital database. Twenty-four
patients who had a VTE event during the 180-day period after enrollment were excluded. We analyzed
the incidence of recurrent VTE, incidence of bleeding events, and predictors in VTE patients. Events were
defined by disease, medication, imaging, and laboratory testing, among other factors.
Results: The rate of recurrence of VTE events was 7.2 per 100 patient-years. The incidence rate of
bleeding events was 8.3 per 100 patient-years. The presence of malignant disease, antipsychotic drugs,
and nonsteroidal anti-inflammatory drugs increased the risk for recurrent VTE. The predictors for
bleeding events were malignant disease, central venous catheterization, cancer chemotherapy, stroke,
and diabetes.
Conclusions: These findings obtained from healthcare database suggest predictors either for recurrent
VTE and bleeding that should be considered when selecting treatment to reduce the risk of recurrent VTE
and mitigate bleeding.
Keywords: Venous thromboembolism | Deep vein thrombosis | Pulmonary embolism | Bleeding event | Healthcare database |
مقاله انگلیسی |
8 |
Usefulness of a healthcare database for epidemiological research in atrial fibrillation
مفید بودن یک پایگاه داده بهداشت و درمان برای تحقیقات اپیدمیولوژیک در فیبریلاسیون دهلیزی-2017 Background: Big data are gaining attention as a valuable resource for providing insights into a range of
issues and questions in healthcare. We evaluated the capacity of a Japanese healthcare database to
conduct epidemiological research in non-valvular atrial fibrillation (NVAF).
Methods and results: We examined data collected between April 2008 and September 2013 in a Japanese
healthcare database. Prior to the risk factor analysis, we validated the criteria for defining the occurrence
of a stroke, systemic embolic event (SEE), and intracranial bleeding event during the study period. The
validity was considered appropriate based on the resulting high positive predictive values. The data of
18,998 NVAF patients demonstrated that the incidence rates of stroke, SEE, and any bleeding events were
2.2, 0.08, and 2.4 per 100 patient-years, respectively. In patients who had not been treated with an
anticoagulant, incidence of stroke significantly increased in higher CHADS2 or CHA2DS2-VASc score,
1.7 and 1.5 fold by 1 point increase, respectively. The use of a proton pump inhibitor (PPI) was also
identified as an independent risk factor for stroke. In patients who had been treated with an anticoagulant,
the independent risk factors for any bleeding events were hypertension, renal dysfunction, hepatic failure,
medical history of stroke, older age (65 years), use of nonsteroidal anti-inflammatory drug, and PPIs.
Conclusion: The data obtained in this study were comparable with results obtained in prospective cohort
studies conducted in Japan.
Keywords: Non-valvular atrial fibrillation | Stroke | Bleeding event | Healthcare database | Validation |
مقاله انگلیسی |
9 |
اگزوسوم (کیسه های کوچک ) در سلول های بنیادی مزانشیمی ، آیا استراتژی درمانی جدید در بیماری های قلبی و عروقی است ؟
سال انتشار: 2015 - تعداد صفحات فایل pdf انگلیسی: 8 - تعداد صفحات فایل doc فارسی: 23 بیماری های قلب و عروق ( CVDs ) هنوز هم یکی از علل عمده ی مرگ و میر افراد در سراسر جهان است و پیوند سلول های بنیادی مزانشیمی (MSCs ) با توجه به ظرفیتشان برای تمایز به سلول های قلبی و عروقی و ترشح سایتوکاین های (cytokine های ) محافظ , که مکانیزم مهمی را در درمان MSC ها برای CVD از خود نشان میدهند , دارای اینده ی خوبی است . اگرچه ظرفیت MSC ها برای تمایز به کاردیومیست ها (CMC ها ) و سلول های اندوتیال (EC) و سلول های صاف عروقی (VSMC) در ازمایش های گسترده ی قبلی , هم در محیط ازمایشگاهی و هم در بدن به خوبی شناخته شده است , میزان بقای پیوند MSC ها در قلب فرد گیرنده , حاکی از این واقعیت است که اثرات درمانی پیوند MSC ها ممکن است با دیگر مکانیسم های زیر بنایی , در ارتباط باشد . شایان ذکر است که بگوییم , مطالعات اخیر نشان داده اند که MSC ها قادر به ترشح مواد سرشار از کلسترول , و اگزوسوم فسفولیپید ها هستند که با RNA های کوچک (mi RNA ها ) غنی شده اند . اگزوسوم های ازاد شده از MSC ها در قلب ها و عروق ها فعالیت میکنند , و سپس شروع به انجام اعمالی از قبیل انتی آپوپتوزیس, بازسازی قلبی , اثرات ضد التهابی , تشکیل عروق نابجا و تجدید سازمان و یا بازسازی ضد عروقی میکنند که به عنوان مکانیسم ملکولی جدید در درمان پیوند سلول های بنیادی مزانشیمی , در نظر گرفته میشوند . ما در اینجا پیشرفت های اخیر را در مورد نقش اگزوسوم ها در درمان MSC ها برای CVD ها خلاصه کرده ایم و در مورد اگزوسوم به عنوان رویکرد جدیدی در درمان CVD ها در اینده , بحث کرده ایم .
کلمات کلیدی : اگزوسوم | micro RNA | سلول های بنیادی مزانشیمی | انفارکتوس میوکارد | آسیب مجدد | فشار خون ریوی |
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