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Spontaneous T. gondii neuronal encystment induces structural neuritic network impairment associated with changes of tyrosine hydroxilase expression
رمزگذاری عصبی T. gondii خودبخودی باعث اختلال در ساختار شبکه عصبی ناشی از تغییرات بیان هیدروکسیلاز تیروزین-2020 Two billion people are chronically infected with Toxoplasma gondii worldwide with unknown consequences.
Important neurological diseases have been associated to the brain infection, making essential to understand the
neurophysiological changes associated with the neuronal encystment. T. gondii may subvert neuronal functions
modifying neurotransmitter concentration in chronically infected mice but the molecular mechanisms involved
are still unclear. Parasites were observed inside neuronal cells in cultures from 24−192 hs. The rate of infection
increased with time. Neurite density decreased affecting network functionality. Neuronal survival was affected
and we detected the presence of cysts inside neuronal bodies and dilated portions of neurites in association with
a relative increase of TH-positive neuritic area without noticeable changes in DA immunofluorescence pattern.
These results advance our knowledge of the interaction between T. gondii and the neuronal network of the host. Keywords: Toxoplasma gondii | Cystogenesis | Tyrosine hydroxylase | Dopamine | Primary neuron culture | Superior cervical ganglion |
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