The integration of cognitive computing and big data analytics leads to a new paradigm that enables the application of the most sophisticated advances in information and communication technology (ICT) in business, including industry, business to business, and related decision-making process. The same paradigm will lead to several breakthroughs in the subfield of industrial marketing: a field both promising and extremely challenging. This special issue makes a case that cognitive computing and big data are a source of a new competitive advantage that, if properly embraced, will further consolidate industrial marketing management position in the of core the decision-making process of businesses operating locally and globally. In this vein, the value added of this special issue is twofold. On the one hand, this special issue communicates high quality research on big data analytics and data science as it is applied in industrial marketing management; On the other hand, it proposes a multidisciplinary approach to the study of the design, implementation and provision of sophisticated applications and systems necessary for data-driven industrial marketing decisions.

Continuous Manufacturing (CM) of pharmaceutical drug products is a new approach within the pharmaceutical industry. In the presented paper, a GMP continuous wet granulation line for production of solid dosage forms was investigated. The line was composed of the subsequent continuous unit: operations feeding – twin-screw wet-granulation – fluid-bed drying – sieving and tableting. The formulation of a commercial entity was selected for this study. Several critical process parameters were evaluated in order to probe the process and to characterize the impact on quality attributes. Seven critical process parameters have been selected after a risk analysis: API and excipient mass flows of the two feeders, liquid feed rate and rotation speed of the extruder and rotation speed, temperature and airflow of the dryer. Eight quality attributes were controlled in real time by Process Analytical Technologies (PAT): API content after blender, after dryer, in tablet press feed frame and of tablet, LOD after dryer and PSD after dryer (three PSD parameters: x10 x50 x90). The process parameter values were changed during production in order to detect the impact on the quality of the final product. The deep learning techniques have been used in order to predict the quality attribute (output) with the process parameters (input). The use of deep learning reduces the noise and simplify the data interpretation for a better process understanding. After optimization, three hidden layers neural network were selected with 6 hidden neurons. The activation function ReLU (Rectified Linear Unit) and the ADAM optimizer were used with 2500 epochs (number of learning cycle). API contents, PSD values and LOD values were estimated with an error of calibration lower than 10%. The level of error allow an adequate process monitoring by DNN and we have proven that the main critical process parameters can be identified at a higher levelof process understanding. The synergy between PAT and process data science creates a superior monitoring framework of the continuous manufacturing line and increase the knowledge of this innovative production line and the products that it makes.
Keywords: Continuous manufacturing | Solid dosage form | Process monitoring | Process analytical technology | Deep learning | Process data science | Process data analytics

Filling the gaps between virtual and physical systems will open new doors in Smart Manufacturing. This work proposes a data-driven approach to utilize digital transformation methods to automate smart manufacturing systems. This is fundamentally enabled by using a digital twin to represent manufacturing cells, simulate system behaviors, predict process faults, and adaptively control manipulated variables. First, the manufacturing cell is accommodated to environments such as computer-aided applications, industrial Product Lifecycle Management solutions, and control platforms for automation systems. Second, a network of interfaces between the environments is designed and implemented to enable communication between the digital world and physical manufacturing plant, so that near-synchronous controls can be achieved. Third, capabilities of some members in the family of Deep Reinforcement Learning (DRL) are discussed with manufacturing features within the context of Smart Manufacturing. Trained results for Deep Q Learning algorithms are finally presented in this work as a case study to incorporate DRL-based artificial intelligence to the industrial control process. As a result, developed control methodology, named Digital Engine, is expected to acquire process knowledges, schedule manufacturing tasks, identify optimal actions, and demonstrate control robustness. The authors show that integrating a smart agent into the industrial platforms further expands the usage of the system-level digital twin, where intelligent control algorithms are trained and verified upfront before deployed to the physical world for implementation. Moreover, DRL approach to automated manufacturing control problems under facile optimization environments will be a novel combination between data science and manufacturing industries.
Keywords: Smart manufacturing systems | Robotics | Artificial intelligence | Digital transformation | Virtual commissioning

Intensive care is an ideal environment for the use of Big Data Analysis (BDA) andMachine Learning (ML), due to the huge amount of information processed and stored in elec-tronic format in relation to such care. These tools can improve our clinical research capabilitiesand clinical decision making in the future.The present study reviews the foundations of BDA and ML, and explores possible applicationsin our field from a clinical viewpoint. We also suggest potential strategies to optimize thesenew technologies and describe a new kind of hybrid healthcare-data science professional witha linking role between clinicians and data.
KEYWORDSBig Data Analysis | Machine Learning | Artificial intelligence | Secondary electronichealth record dataanalysis

This article addresses the role of application programming interfaces (APIs) for integrating data sources in the context of smart cities and communities. On top of the built infrastructures in cities, application programming interfaces allow to weave new kinds of seams from static and dynamic data sources into the urban fabric. Contributing to debates about ‘‘urban informatics’’ and the governance of urban information infrastructures, this article provides a technically informed and critically grounded approach to evaluating APIs as crucial but often overlooked elements within these infrastructures. The conceptualization of what we term City APIs is informed by three perspectives: In the first part, we review established criticisms of proprietary social media APIs and their crucial function in current web architectures. In the second part, we discuss how the design process of APIs defines conventions of data exchanges that also reflect negotiations between API producers and API consumers about affordances and mental models of the underlying computer systems involved. In the third part, we present recent urban data innovation initiatives, especially CitySDK and OrganiCity, to underline the centrality of API design and governance for new kinds of civic and commercial services developed within and for cities. By bridging the fields of criticism, design, and implementation, we argue that City APIs as elements of infrastructures reveal how urban renewal processes become crucial sites of socio-political contestation between data science, technological development, urban management, and civic participation.
Keywords: Application Programming Interface (API) | infrastructure | Internet of Things (IoT) | interface design | social urban data | smart city