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Apolipoproteins AI and E are associated with neuroaxonal injury to gray matter in multiple sclerosis
آپولیپوپروتئین های AI و E همراه با آسیب عصبی آکسون ماده خاکستری در بیماری ام اس-2020 Purpose To investigate the associations between longitudinal changes in lipid biomarkers and serum neurofilament
(sNfL) levels in multiple sclerosis (MS) neurodegeneration and disease progression.
Methods 5-year prospective, longitudinal study included 75 relapsing-remitting MS (RR-MS) and 37 progressive-
MS (P-MS) patients. sNfL, plasma total cholesterol (TC), high-density (HDL-C) and low-density (LDL-C)
lipoprotein cholesterol, apolipoproteins (Apo), ApoA-I, Apo-II, ApoB, ApoC-II and ApoE were measured at
baseline and 5-years. Annual percent changes in whole brain volume (PBVC), gray matter volume (PGMVC) and
cortical volume (PCVC) were obtained from MRI at baseline and 5-years.
Results sNfL levels at 5-year follow-up were associated with ApoE at follow-up (p = 0.014), age at follow-up,
body mass index (p<0.001) and RR vs. P-MS status at follow-up. APOE4 allele was associated with greater sNfL
levels at 5-years (p = 0.022) and pronounced in the P-MS group. PGMVC and PCVC were associated with
percent changes in HDL-C (p = 0018 and p < 0.001, respectively) and ApoA-I (p = 0.0073 and p = 0.006).
PGMVC and PCVC remained associated with percent change in HDL-C (p = 0.0024 and p < 0.001, respectively)
after sNfL was included as a predictor.
Conclusions HDL-C percent change is associated with decreased gray matter atrophy after adjusting for
baseline sNfL. Keywords: Cholesterol | High density lipoprotein | Hdl | Apolipoproteins | Neurofilaments |
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