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نتیجه جستجو - Hodgkin-Huxley model

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ردیف عنوان نوع
1 Computational analysis of NIRS and BOLD signal from neurovascular coupling with three neuron-system feedforward inhibition network
تجزیه و تحلیل محاسباتی سیگنال های NIRS و BOLD از اتصال جفت عصبی عروقی با سه شبکه مهار کننده تغذیه ای سیستم عصبی-2020
Several neurological disorders occur due to hypoxic condition in brain arising from impairment of cere- bral functionality, which can be controlled by neural stimulation driven vasoactive response mediated through biological response in astrocyte, a phenomenon known as neurovascular coupling. Brain can ad- just with the problem of hypoxic condition by causing vasodilation with the help of this mechanism. To deduce the mechanism behind vasodilation of blood vessel caused by neuronal stimulus, current study articulates a mathematical model involving neuronal system feedforward inhibition network model (FFI) with two other functional components of neurovascular coupling, i.e. astrocyte and smooth muscle cell lining blood vessel. This study includes the neural inhibition network system where glutamatergic pyra- midal neuron and GABAergic interneuron act antagonistically with each other. The proposed model suc- cessfully includes the implication of the inhibition system to design mathematical model for neurovas- cular coupling. Result of the proposed model shows that the increase in neuronal stimulus from 20 to 60 μA/cm 2 has the ability to increase the vasodilatory activity of blood tissue vasculature. Oxygenation level and hemodynamic response due to input synaptic stimulation has been calculated by regional cere- bral oxygenation level (rS0 2 ) and blood oxygen level dependent (BOLD) imaging signal which supports vasodilation of blood vessel with increase in synaptic input stimulus.
Keywords: Neurovascular coupling unit | Hodgkin-Huxley model | Neurotransmitter | Feedforward-inhibition network | Regional cerebral oxygen saturation
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