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Individualizing Care
مراقبت شخصی-2020 The forthcoming availability of several novel drugs in primary biliary cholangitis (PBC)
coupled with the rise of high-throughput omics technologies prompt changing the paradigm
of the management of the disease.
Precision medicine (PM), through the application of omics-based approaches, should enable
identifying disease variants, stratifying patients according to disease trajectory, risk of disease
progression, and likelihood of response to different therapeutic options in PBC.
The development of PM needs specific interventions, such as sequencing more genomes,
creating bigger biobanks, and linking biological information to health data in electronic
medical record.
The authors envisage that a diagnostic work-up of PBC patients will include information
on genetic variants and molecular signature that may define a particular subtype of disease
and provide an estimate of treatment response and survival KEYWORDS : Primary biliary cholangitis | Precision medicine | Risk-stratification | Autoimmune liver disease | Individualized care | Novel therapies | Omics |
مقاله انگلیسی |
2 |
Cross-sector collaboration for vulnerable populations reduces utilization and strengthens community partnerships
همکاری بین بخشی برای جمعیت های آسیب پذیر باعث کاهش استفاده و تقویت مشارکت های جامعه می شود-2020 Adventist Health Clear Lake is located in one of the poorest counties in California, with health rankings in the
lowest decile of the state. Fire devastation, lack of affordable housing, modest employment opportunities, and
widespread addiction have stretched the limited resources of the response system in this rural community. An
innovative, cross-sector, interprofessional collaborative was formed to address the needs of community members
who were high utilizers of the police, emergency, criminal justice, and healthcare systems.
The collaborative approach was associated with a 44% reduction in hospital utilization, an 83% reduction in
community response system usage, and a 71% reduction in costs for the population. Cross-sector, interprofessional
collaboration between community agencies that share a select group of community members is an effective
way to stabilize care, decrease healthcare and community system overutilization, improve care delivery,
and reduce the costs of associated care. Keywords: Cross-sector | Cross-continuum care collaboration | Cross-sector collaboration | Competing health systems | Integrated care | High need patient | igh frequency patient | Complex patient | Chronic patient | Emergency department | Individualized care | Decrease readmissions | Preventable hospitalization | Cost reduction | Root cause | Interprofessional team | Interorganizational team | Integrated behavioral health | Overuse | Overutilization | Super utilizers |
مقاله انگلیسی |