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نتیجه جستجو - Neutropenia

تعداد مقالات یافته شده: 3
ردیف عنوان نوع
1 Student nurses knowledge about the management of chemotherapy-induced neutropenia: Multi-national survey
دانش پرستاران دانشجویی در مورد مدیریت نوتروپنی ناشی از شیمی درمانی: مرور چند ملیتی-2021
Background: Chemotherapy-induced neutropenia is a serious global health concern. It is essential that student nurses who are the future of healthcare are equipped with the right knowledge to care for the unique needs of patients with neutropenia.
Objective: The study assesses student nurses’ knowledge of neutropenia management and examines the difference in their knowledge with regard to their demographics. Design: A descriptive cross-sectional survey design was used. Settings: Participants for this survey were recruited from four nursing schools from three countries: Jordan, Oman, and Saudi Arabia.
Participants: The study sample comprised 230 student nurses representing all three countries. Methods: Online data collection was implemented. A message including the link to the study questionnaire was sent to students through their university portal. Demographic data and the neutropenia knowledge questionnaire were collected.
Results: The student nurses showed poor knowledge of neutropenia and its management (mean = 10.1 out of 30). The bridging students (M = 12.6, SD = 9.8) had significantly higher mean total knowledge scores than the regular students (M = 9.8, SD = 5.5) (t = 2.9, df = 38.9, p = 0.006). However, students who had received previous education about neutropenia management (M = 11.6, SD = 5.0) had significantly higher mean knowledge scores than those who had not (M = 9.5, SD = 5.6) (t = − 2.73, df = 134.8, p = 0.007).
Conclusions: The study findings underscore the overarching necessity to improve students’ knowledge of neutropenia and its management. However, addressing this concern is multifaceted and requires deliberate effort from various agencies. Developing innovative strategies to increase the coverage of oncology nursing in the curriculum, improving faculty expertise, enhancing staff nurses’ knowledge and skills, provision of funding, and adoption of oncology-related competencies in the nursing program need to be explored as key solutions.
keywords: دانش | نوتروپنی | نوتروپنی ناشی از شیمی درمانی | دانش آموزان: پرستاری | پرستاری انکولوژی | نئوپلاسم | Knowledge | Neutropenia | Chemotherapy-induced febrile neutropenia | Students: nursing | Oncology nursing | Neoplasm
مقاله انگلیسی
2 Prediction of irinotecan toxicity in metastatic colorectal cancer patients based on machine learning models with pharmacokinetic parameters
پیش بینی سمیت ایرینوتکان در بیماران مبتلا به سرطان روده بزرگ متاستاتیک بر اساس مدل های یادگیری ماشین با پارامترهای فارماکوکینتیک-2019
Irinotecan (CPT-11) is a drug used against a wide variety of tumors, which can cause severe toxicity, possibly leading to the delay or suspension of the cycle, with the consequent impact on the prognosis of survival. The main goal of this work is to predict the toxicities derived from CPT-11 using artificial intelligence methods. The data for this study is conformed of 53 cycles of FOLFIRINOX, corresponding to patients with metastatic colorectal cancer. Supported by several demographic data, blood markers and pharmacokinetic parameters resulting from a non-compartmental pharmacokinetic study of CPT-11 and its metabolites (SN-38 and SN-38-G), we use machine learning techniques to predict high degrees of different toxicities (leukopenia, neutropenia and diarrhea) in new patients. We predict high degree of leukopenia with an accuracy of 76%, neutropenia with 75% and diarrhea with 91%. Among other variables, this study shows that the areas under the curve of CPT-11, SN-38 and SN-38-G play a relevant role in the prediction of the studied toxicities. The presented models allow to predict the degree of toxicity for each cycle of treatment according to the particularities of each patient.
Keywords: Colorectal cancer | Irinotecan | Machine learning | Pharmacokinetics | Toxicity
مقاله انگلیسی
3 Infections after Transplantation of Bone Marrow or Peripheral Blood Stem Cells from Unrelated Donors
عفونت بعد از پیوند مغز استخوان و یا محیطی سلول های بنیادی خون از اهداکنندگان غیروابسته-2016
Infection is a major complication of hematopoietic cell transplantation. Prolonged neutropenia and graftversus-host disease are the 2 major complications with an associated risk for infection, and these complications differ according to the graft source. A phase 3, multicenter, randomized trial (Blood and Marrow Transplant Clinical Trials Network [BMT CTN] 0201) of transplantation of bone marrow (BM) versus peripheral blood stem cells (PBSC) from unrelated donors showed no significant differences in 2-year survival between these graft sources. In an effort to provide data regarding whether BM or PBSC could be used as a preferential graft source for transplantation, we report a detailed analysis of the infectious complications for 2 years after transplantation from the BMT CTN 0201 trial. A total of 499 patients in this study had full audits of infection data. A total of 1347 infection episodes of moderate or greater severity were documented in 384 (77%) patients; 201 of 249 (81%) of the evaluable patients had received a BM graft and 183 of 250 (73%) had received a PBSC graft. Of 1347 infection episodes, 373 were severe and 123 were life-threatening and/or fatal; 710 (53%) of these episodes occurred on the BM arm and 637 (47%) on the PBSC arm, resulting in a 2-year cumulative incidence 84.7% (95% confidence interval [CI], 79.6 to 89.8) for BM versus 79.7% (95% CI, 73.9 to 85.5) for PBSC, P ¼ .013. The majority of these episodes, 810 (60%), were due to bacteria, with a 2-year cumulative incidence of 72.1% and 62.9% in BM versus PBSC recipients, respectively (P ¼ .003). The cumulative incidence of bloodstream bacterial infections during the first 100 days was 44.8% (95% CI, 38.5 to 51.1) for BM versus 35.0% (95% CI, 28.9 to 41.1) for PBSC (P ¼ .027). The total infection density (number of infection events/100 patient days at risk) was .67 for BM and .60 for PBSC. The overall infection density for bacterial infections was .4 in both arms; for viral infections, it was .2 in both arms; and for fungal/parasitic infections, it was .04 and .05 for BM and PBSC, respectively. The cumulative incidence of infection before engraftment was 47.9% (95% CI, 41.5 to 53.9) for BM versus 32.8% (95% CI, 27.1 to 38.7) for PBSC (P ¼ .002), possibly related to quicker neutrophil engraftment using PBSC. Infections remain frequent after unrelated donor hematopoietic cell transplantation, particularly after BM grafts.
Key Words: Infection | Unrelated donor | transplantation | Bacteremia | Cytomegalovirus | Aspergillosis | Pre-engraftment
مقاله انگلیسی
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