با سلام خدمت کاربران در صورتی که با خطای سیستم پرداخت بانکی مواجه شدید از طریق کارت به کارت (6037997535328901 بانک ملی ناصر خنجری ) مقاله خود را دریافت کنید (تا مشکل رفع گردد).
ردیف | عنوان | نوع |
---|---|---|
1 |
Serotonin induces Arcadlin in hippocampal neurons
سروتونین آرکادلین را در سلول های عصبی هیپوکامپ القا می کند-2020 The monoamine hypothesis does not fully explain the delayed onset of recovery after antidepressant treatment or
the mechanisms of recovery after electroconvulsive therapy (ECT). The common mechanism that operates both
in ECT and monoaminergic treatment presumably involves molecules induced in both of these conditions. A
spine density modulator, Arcadlin (Acad), the rat orthologue of human Protocadherin-8 (PCDH8) and of Xenopus
and zebrafish Paraxial protocadherin (PAPC), is induced by both electroconvulsive seizure (ECS) and antidepressants;
however, its cellular mechanism remains elusive. Here we confirm induction of Arcadlin upon
stimulation of an N-methyl-D-aspartate (NMDA) receptor in cultured hippocampal neurons. Stimulation of an
NMDA receptor also induced acute (20 min) and delayed (2 h) phosphorylation of the p38 mitogen-activated
protein (MAP) kinase; the delayed phosphorylation was not obvious in Acad–/– neurons, suggesting that it depends
on Arcadlin induction. Exposure of highly mature cultured hippocampal neurons to 1–10 μM serotonin for
4 h resulted in Arcadlin induction and p38 MAP kinase phosphorylation. Co-application of the NMDA receptor
antagonist D-(-)-2-amino-5-phosphonopentanoic acid (APV) completely blocked Arcadlin induction and p38
MAP kinase phosphorylation. Finally, administration of antidepressant fluoxetine in mice for 16 days induced
Arcadlin expression in the hippocampus. Our data indicate that the Arcadlin-p38 MAP kinase pathway is a
candidate neural network modulator that is activated in hippocampal neurons under the dual regulation of
serotonin and glutamate and, hence, may play a role in antidepressant therapies. Keywords: Serotonin | Protocadherin | Adhesion | Synaptic plasticity | Antidepressant | Mitogen-activated protein kinase |
مقاله انگلیسی |