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نتیجه جستجو - Radiosensitivity

تعداد مقالات یافته شده: 2
ردیف عنوان نوع
1 Deep learning-assisted literature mining for in vitro radiosensitivity data
استخراج ادبیات با کمک یادگیری عمیق برای داده های تابش آزمایشگاهی -2019
Background and purpose: Integrated analysis of existing radiosensitivity data obtained by the goldstandard clonogenic assay has the potential to improve our understanding of cancer cell radioresistance. However, extraction of radiosensitivity data from the literature is highly labor-intensive. To aid in this task, using deep convolutional neural networks (CNNs) and other computer technologies, we developed an analysis pipeline that extracts radiosensitivity data derived from clonogenic assays from the literature. Materials and methods: Three classifiers (C1–3) were developed to identify publications containing radiosensitivity data derived from clonogenic assays. C1 uses Faster Regions CNN with Inception Resnet v2 (fRCNN-IRv2), VGG-16, and Optical Character Recognition (OCR) to identify publications that contain semi-logarithmic graphs showing radiosensitivity data derived from clonogenic assays. C2 uses fRCNN-IRv2 and OCR to identify publications that contain bar graphs showing radiosensitivity data derived from clonogenic assays. C3 is a program that identifies publications containing keywords related to radiosensitivity data derived from clonogenic assays. A program (iSF2) was developed using Mask RCNN and OCR to extract surviving fraction after 2-Gy irradiation (SF2) as assessed by clonogenic assays, presented in semi-logarithmic graphs. The efficacy of C1–3 and iSF2 was tested using seven datasets (1805 and 222 publications in total, respectively). Results: C1–3 yielded sensitivity of 91.2% ± 3.4% and specificity of 90.7% ± 3.6%. iSF2 returned SF2 values that were within 2.9% ± 2.6% of the SF2 values determined by radiation oncologists. Conclusion: Our analysis pipeline is potentially useful to acquire radiosensitivity data derived from clonogenic assays from the literature.
Keywords: Clonogenic assays | Radiosensitivity | Deep learning | Convolutional neural networks | Radiation oncology
مقاله انگلیسی
2 Les big data, généralités et intégration en radiothérapie
داده های بزرگ، ژنتیک و مقیاس پذیری در محیط زیست-2018
The many advances in data collection computing systems (data collection, database, storage), diagnostic and therapeutic possibilities are responsible for an increase and a diversification of available data. Big data offers the capacities, in the field of health, to accelerate the discoveries and to optimize the management of patients by combining a large volume of data and the creation of therapeutic models. In radiotherapy, the development of big data is attractive because data are very numerous et heterogeneous (demographics, radiomics, genomics, radiogenomics, etc.). The expectation would be to predict the effectiveness and tolerance of radiation therapy. With these new concepts, still at the preliminary stage, it is possible to create a personalized medicine which is always more secure and reliable.
Keywords: Big data , Radiotherapy , Predictive model , Cancer , Genomics , Radiosensitivity
مقاله انگلیسی
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