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Optimizing the electrical conductivity of polyacrylonitrile/polyaniline with nickel nanoparticles for the enhanced electrostimulation of Schwann cells proliferation
بهینه سازی رسانایی الکتریکی پلی اکریلونیتریل/پلی آنیلین با نانوذرات نیکل برای تحریک الکتریکی افزایش یافته تکثیر سلول های شوان-2021 Tissue engineering scaffolds made of biocompatible polymers are promising alternatives for nerve reparation. For this application, cell proliferation will be speeded up by electrostimulation, which required
electrically-conductive materials. Here, a biomimicking scaffold with optimized conductivity was developed from electrospun polyacrylonitrile/electrically-conductive polyaniline (PAN/PANI) nanofibers
doped with Ni nanoparticles. PAN/PANI/Ni was biocompatible for Schwann cells and exhibited a suitable
tensile strength and wettability for cell proliferation. When compared with unmodified PAN/PANI, the
electrical conductivity of PAN/PANI/Ni was 6.4 fold higher. Without electrostimulation, PAN/PANI and
PAN/PANI/Ni exhibited similar Schwann cells’ proliferation rates. Upon electrostimulation at
100 mV cm1 for one hour per day over five days, PAN/PANI/Ni accelerated Schwann cells’ proliferation
2.1 times compared to PAN/PANI. These results demonstrate the importance of expanding the electrical
conductivity of the tissue engineering scaffold to ensure optimal electrostimulation of nerve cell growth.
Additionally, this study describes a straightforward approach to modulate the electrical conductivity of
polymeric materials via the addition of Ni nanoparticles that can be applied to different biomimicking
scaffolds for nerve healing.
Keywords: Nerve tissue engineering | Electrospinning | PAN/PANI | Ni nanoparticles | Schwann cells |
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