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Using Big Data to Discover Diagnostics and Therapeutics for Gastrointestinal and Liver Diseases
استفاده از داده های بزرگ برای کشف تشخیص و درمان برای دستگاه گوارش و کبد-2017 Technologies such as genome sequencing, gene expression
profiling, proteomic and metabolomic analyses, electronic
medical records, and patient-reported health information
have produced large amounts of data from various populations, cell types, and disorders (big data). However,
these data must be integrated and analyzed if they are to
produce models or concepts about physiological function
or mechanisms of pathogenesis. Many of these data are
available to the public, allowing researchers anywhere to
search for markers of specific biological processes or
therapeutic targets for specific diseases or patient types.
We review recent advances in the fields of computational
and systems biology and highlight opportunities for
researchers to use big data sets in the fields of gastroenterology and hepatology to complement traditional means
of diagnostic and therapeutic discovery.
Keywords: Big Data | Translational Bioinformatics | Drug Repurposing | Precision Medicine. |
مقاله انگلیسی |