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Optimizing the electrical conductivity of polyacrylonitrile/polyaniline with nickel nanoparticles for the enhanced electrostimulation of Schwann cells proliferation
بهینه سازی رسانایی الکتریکی پلی اکریلونیتریل/پلی آنیلین با نانوذرات نیکل برای تحریک الکتریکی افزایش یافته تکثیر سلول های شوان-2021 Tissue engineering scaffolds made of biocompatible polymers are promising alternatives for nerve reparation. For this application, cell proliferation will be speeded up by electrostimulation, which required
electrically-conductive materials. Here, a biomimicking scaffold with optimized conductivity was developed from electrospun polyacrylonitrile/electrically-conductive polyaniline (PAN/PANI) nanofibers
doped with Ni nanoparticles. PAN/PANI/Ni was biocompatible for Schwann cells and exhibited a suitable
tensile strength and wettability for cell proliferation. When compared with unmodified PAN/PANI, the
electrical conductivity of PAN/PANI/Ni was 6.4 fold higher. Without electrostimulation, PAN/PANI and
PAN/PANI/Ni exhibited similar Schwann cells’ proliferation rates. Upon electrostimulation at
100 mV cm1 for one hour per day over five days, PAN/PANI/Ni accelerated Schwann cells’ proliferation
2.1 times compared to PAN/PANI. These results demonstrate the importance of expanding the electrical
conductivity of the tissue engineering scaffold to ensure optimal electrostimulation of nerve cell growth.
Additionally, this study describes a straightforward approach to modulate the electrical conductivity of
polymeric materials via the addition of Ni nanoparticles that can be applied to different biomimicking
scaffolds for nerve healing.
Keywords: Nerve tissue engineering | Electrospinning | PAN/PANI | Ni nanoparticles | Schwann cells |
مقاله انگلیسی |
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3D-printable conductive materials for tissue engineering and biomedical applications
مواد رسانای قابل چاپ سه بعدی برای مهندسی بافت و کاربردهای زیست پزشکی-2021 Many patients that undergo autografting suffer from donor site morbidity and risk of immune rejection. Tissue
engineering is receiving considerable attention as engineered tissues could help overcome the drawbacks of
autografts and achieve better performance on tissue repair, replacement and regeneration. Conductivity is one of
the desired properties of engineered scaffolds and tissue constructs as bioelectricity plays an important role in the
native physiological environment. Hence, conductive materials have been extensively used in the making of
biosensors, tissue engineering scaffolds and drug delivery systems to elicit electrically-mediated signals, thus
mimicking the natural cellular environment. Conductive polymers, carbon-based materials, and metal nanoparticles are the main categories of conductive materials used. Ionic liquids, especially biocompatible ionic
liquids, is currently being explored as a competitive filler composite to greatly improve the conductivity of
polymers with little to zero cytotoxicity. The effects of electrical stimulation on cell alignment, migration,
proliferation, and differentiation as well as detailed properties of different types of conductive materials are
briefly yet succinctly reviewed. Furthermore, 3D printing of conductive scaffolds and hydrogels, and their corresponding biomedical applications are also discussed.
Keywords: Conductive biomaterials | Bioprinting | Tissue engineering | Ionic liquids | Electrical stimulation |
مقاله انگلیسی |
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تکنیک حذف آرتیفکت تحریک برای پردازش سیگنال SEMG در طی تحریک الکتریکی عملکردی (FES)
سال انتشار: 2015 - تعداد صفحات فایل pdf انگلیسی: 9 - تعداد صفحات فایل doc فارسی: 33 هدف اين مطالعه طراحي يك روش براي استخراج EMG ارادي از الكترومايوگرافي سطحي ثبتشده ، آلودهشده توسط آرتیفکت تحريك الكتريكي كاربردي بود.
متد:با توجه به اينكه آرتیفکت FESبهطور پريوديك با اندازه نسبتا بزرگ در EMG نا ايستا ظاهر میشود،ما يك فيلتر تطابقي منطبق با بهينه سازي الگوريتم ژنتيك طراحي كرديم هر دو ديتاي شبیهسازیشده و واقعي از هفت سوژه توسط فيلتر ژنتيك و فيلتر كامب(شانه) بدست امد.براي ازمايش تاثير فيلتر بر روي EMG الوده شده با ارتيفكت FESبا شدت هاي مختلف ،EMG الوده شده با تركيب ارتيفكت شبيه سازي و EMG تمیز با ارتيفكت هاي FESمتفاوت به نسبت EMG تمیز ،تحریک شد.
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