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نتیجه جستجو - ترجمه دانش

تعداد مقالات یافته شده: 3
ردیف عنوان نوع
1 Pain management for infants – Myths, misconceptions, barriers; knowledge and knowledge gaps
مدیریت درد برای نوزادان - افسانه ها، باورهای غلط، موانع؛ دانش و شکاف دانش-2021
Twelve years ago, the paper ‘Oral sucrose for pain management in infants: Myths and misconceptions’ was published in the Journal of Neonatal Nursing. At this time, eight myths or misconceptions were addressed. Since this time there has been more than 100 studies published reporting on analgesic effects of sweet solutions in newborns, which have been synthesised and included in systematic reviews. There has also been a growth of literature to support analgesic effects of breastfeeding and skin-to-skin care as well as concerning evidence of adverse long-term neurobehavioural outcomes associated with painful procedures. Yet, ongoing studies of pain management practices continue to report inconsistent use of these strategies during painful procedures. We are therefore at a cross-roads of evidence – there is knowledge of effective treatments, knowledge of harm of untreated pain, yet sick, premature as well as healthy infants are continuing to be exposed to painful procedures with no effective treatment. There are however ongoing myths, misconceptions, and practical barriers to using the evidence as well as ongoing knowledge gaps. This paper will therefore highlight existing myths, misconceptions, barriers and current knowledge gaps to using the three key evidence-based pain management strategies of breastfeeding, skin-to-skin care and sweet solutions, in the hope that this will bring to light newborn infant pain treatment practices that can be improved.
keywords: پرستاری | نوزاد تازه | درد | درمان درد | شیر دادن | ساکاروز | پوست به پوست | نوزاد | ترجمه دانش | پژوهش | Nursing | Newborn | Pain | Pain treatment | Breastfeeding | Sucrose | Skin-to-skin | Neonate | Knowledge translation | Research
مقاله انگلیسی
2 Time management: Improving the timing of post-prostatectomy radiotherapy, clinical trials, and knowledge translation
مدیریت زمان: بهبود زمان رادیوتراپی پس از پروستاتکتومی، آزمایشات بالینی و ترجمه دانش-2021
Background: Management of prostate cancer after surgery is controversial. Past studies on adjuvant radiotherapy (aRT) for higher-risk features have had conflicting results. Through the collaborative conversations of the global radiation oncology Twitter-based journal club (#RadOnc #JC), we explored this complex topic to share recent advances, better understand what the global radiation oncology community felt was important and inspire next steps. Methods: We selected the recent publication of a landmark international randomized controlled trial (RCT) comparing immediate and salvage radiotherapy for prostate cancer, RADICALS-RT, for discussion over the weekend of January 16 to 17, 2021. Coordination included open access to the article and an asynchronous portion to decrease barriers to participation, cooperation of study authors (CP, MS) who participated to share deeper insights including a live hour, and curation of related resources and tweet content through a blog post and Wakelet journal club summary. Discussion of Results: Our conversations created 2,370,104 impressions over 599 tweets with 51 participants spanning 11 countries and 5 continents. A quarter of the participants were from the US (13/51) followed by 10% from the UK (5/51). Clinical or Radiation Oncologists comprised 59% of active participants (16/27) with 62% (18/29) reporting giving aRT within the last 5 years. Discussion was interdisciplinary with three urologists (11%), three trainees (11%), and two physiotherapists (7%). Four months after the journal club its article Altmetric score had increased by 7% (214 to 229). Thematic analysis of tweet content suggested participants wanted clarification on definitions of adjuvant (aRT) and salvage radiotherapy (sRT) including indications, timing, and decision-making tools including guidelines; more interdisciplinary and cross-sectoral collaboration including with patients for study design including survivorship and meaningful outcomes; more effective knowledge translation including faster clinical trials; and more data including mature results of current trials, particular high-risk features (Gleason Group 4+, pT4b+, and margin-positive disease), implications of newer technologies such as PSMA-PET and genomic classifiers, and better explanations for practice pattern variations including underutilization of radiotherapy. This was further explored in the context of relevant literature. Conclusion: Together, this global collaborative review on the postoperative management of prostate cancer suggested a stronger signal for the uptake of early salvage radiation treatment with careful PSA monitoring, more sensitive PSA triggers, and expected access to radiotherapy. Questions still remain on potential exceptions and barriers to use. These require better decision-making tools for all practice settings, consideration of newer technologies, more pragmatic trials, and better use of social media for knowledge translation.
Keywords: Prostate radiotherapy | Adjuvant radiation | Salvage radiation | Journal club
مقاله انگلیسی
3 Chronic Liver Diseases and the Microbiome-Translating Our Knowledge of Gut Microbiota to Management of Chronic Liver Disease
بیماری های مزمن کبدی و میکروبیوم - ترجمه دانش ما از میکروبیوتا روده به مدیریت بیماری مزمن کبدی-2021
Chronic liver disease is reaching epidemic proportions with the increasing prevalence of obesity, nonalcoholic liver disease, and alcohol overuse worldwide. Most patients are not candidates for liver transplantation even if they have end-stage liver disease. There is growing evidence of a gut microbial basis for many liver diseases, therefore, better diagnostic, prognostic, and therapeutic approaches based on knowledge of gut microbiota are needed. We review the questions that need to be answered to successfully translate our knowledge of the intestinal microbiome and the changes associated with liver disease into practice.
Keywords: Cirrhosis | Hepatic Encephalopathy | Fecal Microbial Transplant | Diet.
مقاله انگلیسی
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