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Modulation of Frequency Preference in Heterogeneous Populations of Theta-resonant Neurons
مدولاسیون اولویت فرکانس در جمعیت ناهمگن نورون های تتا-رزونانس-2020 Abstract—Neurons from several brain regions resonate in the theta frequency range (4–12 Hz), displaying a higher
voltage response to oscillatory currents at a preferred ‘resonant’ frequency (fR). Subthreshold resonance could
influence spiking and contribute to the selective entrainment of neurons during the network oscillatory activity
that accompanies several cognitive processes. Neurons from different regions display resonance in specific theta
subranges, suggesting a functional specialization. Further experimental work is needed to characterize this diversity
and explore how frequency preference could be dynamically modulated. Theoretical studies have shown that
the fine-tuning of resonance depends in a complex way on a variety of intrinsic factors and input properties, but
their specific influence is difficult to dissect in cells. We performed slice electrophysiology, dynamic clamping
and modelling to assess the differential frequency preference of rat entorhinal stellate neurons, hippocampal
CA1 pyramidal neurons and cortical amygdala neurons, which share a hyperpolarization-activated current (Ih)-
dependent resonance mechanism. We found heterogeneous resonance properties among the different types of
theta-resonant neurons, as well as in each specific group. In all the neurons studied, fR inversely correlated with
the effective input resistance (Rin), a measurable variable that depends on passive and active membrane features.
We showed that resonance can be adjusted by manipulations mimicking naturally occurring processes, as the
incorporation of a virtual constant conductance or cell depolarization, in a way that preserves the fR-Rin relationship.
The modulation of frequency selectivity influences firing by shifting spike frequency and timing, which
could influence neuronal communication in an active network. 2019 IBRO. Published by Elsevier Ltd. All rights
reserved. Key words: theta-frequency resonance | frequency modulation | input resistance | resonant frequency | phase-lag | spike timing |
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