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What electrophysiology tells us about Alzheimer’s disease: a window into the synchronization and connectivity of brain neurons
آنچه الکتروفیزیولوژی در مورد بیماری آلزایمر به ما می گوید: پنجره ای برای هماهنگ سازی و اتصال نورون های مغز-2020 Electrophysiology provides a real-time readout of neural functions and network capability in different
brain states, on temporal (fractions of milliseconds) and spatial (micro, meso, and macro) scales unmet
by other methodologies. However, current international guidelines do not endorse the use of electroencephalographic
(EEG)/magnetoencephalographic (MEG) biomarkers in clinical trials performed in
patients with Alzheimer’s disease (AD), despite a surge in recent validated evidence. This position paper
of the ISTAART Electrophysiology Professional Interest Area endorses consolidated and translational
electrophysiological techniques applied to both experimental animal models of AD and patients, to probe
the effects of AD neuropathology (i.e., brain amyloidosis, tauopathy, and neurodegeneration) on
neurophysiological mechanisms underpinning neural excitation/inhibition and neurotransmission as
well as brain network dynamics, synchronization, and functional connectivity, reflecting thalamocortical
and corticocortical residual capacity. Converging evidence shows relationships between abnormalities in
EEG/MEG markers and cognitive deficits in groups of AD patients at different disease stages. The supporting
evidence for the application of electrophysiology in AD clinical research as well as drug discovery
pathways warrants an international initiative to include the use of EEG/MEG biomarkers in the main
multicentric projects planned in AD patients, to produce conclusive findings challenging the present
regulatory requirements and guidelines for AD studies. Keywords: The Alzheimer’s Association International | Society to Advance Alzheimer’s Research | and Treatment (ISTAART) | Alzheimer’s disease (AD) | Electroencephalography and | magnetoencephalography (EEG and MEG) | Resting-state condition | Event-related potentials and magnetic fields | Preclinical and clinical research |
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