با سلام خدمت کاربران در صورتی که با خطای سیستم پرداخت بانکی مواجه شدید از طریق کارت به کارت (6037997535328901 بانک ملی ناصر خنجری ) مقاله خود را دریافت کنید (تا مشکل رفع گردد).
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1 |
Combination of a big data analytics resource system with an artificial intelligence algorithm to identify clinically actionable radiation dose thresholds for dysphagia in head and neck patients
ترکیبی از یک سیستم منبع تحلیلی داده های بزرگ با یک الگوریتم هوش مصنوعی برای شناسایی آستانه های دوز پرتودرمانی از نظر بالینی برای دیسفاژی در بیماران سر و گردن-2020 Purpose/Objective(s): We combined clinical practice changes, standardizations and
technology to automate aggregation, integration and harmonization of comprehensive
patient data from the multiple source systems used in clinical practice into a big data
analytics resource system (BDARS). We then developed novel artificial intelligence (AI)
algorithms, coupled to the BDARS, to identify structure DVH metrics associated with
dysphagia.
Materials/Methods: From the BDARS harmonized data of ≥ 22,000 patients, we
identified 132 patients recently treated for head and neck cancer who also demonstrated
dysphagia scores that worsened from base line to a maximum grade ≥ 2. We developed a
method that used both physical and biologically corrected (α/β =2.5) DVH curves to test
both absolute and percentage volume based DVH metrics. Combining a statistical
categorization algorithm with machine learning (SCA-ML) the method provided more
extensive detailing of response threshold evidence than either approach alone. A
sensitivity guided, minimum input ML model was iteratively constructed to identify the
key structure DVH metric thresholds.
Results: Seven swallowing structures producing 738 candidate DVH metrics were
ranked for association with dysphagia using SCA-ML scoring. Structures included
superior pharyngeal constrictor (SPC), inferior pharyngeal constrictor (IPC), larynx,
esophagus. Bilateral parotid and submandibular gland (SG) structures were categorized
by relative mean dose (e.g SG_High, SG_Low) as a dose vs tumor centric analog to
contra and ipsilateral designations. Structure – DVH metrics with high SCA-ML scores
included SPC:D20%[EQD2Gy] ≥ 47.7, SPC:D25%[Gy] ≥ 50.4, IPC:D35%[Gy] ≥ 61.7,
Parotid_Low:D60%[Gy] ≥ 13.2 and SG_High:D35%[Gy] ≥ 61.7. Larynx:D25%[Gy] ≥
21.2 and SG_Low:D45%≥28.2 had high SCA-ML scores, but were segmented on fewer
than 90% of plans. A model based on SPC:D20%[EQD2Gy] alone had sensitivity and
AUC of 0.88 ±0.13 and 0.74 ± 0.17 respectively.
Conclusion: This study provides practical demonstration of combining big data with
AI to increase volume of evidence in clinical learning paradigms |
مقاله انگلیسی |
2 |
Optimizing the induction chemotherapy regimen for patients with locoregionally advanced nasopharyngeal Carcinoma: A big-data intelligence platform-based analysis
بهینه سازی رژیم شیمی درمانی القایی برای بیماران مبتلا به سرطان نازوفارنکس پیشرفته locoregionally: یک تجزیه و تحلیل مبتنی بر پلت فرم اطلاعات داده های بزرگ-2018 Objectives: This study aimed at identifying the optimal induction chemotherapy regimen for patients with lo
coregionally advanced nasopharyngeal carcinoma (NPC) treated by intensity-modulated radiotherapy.
Materials and methods: We identified eligible patients with newly-diagnosed stage III-IVA NPC (excluding T3N0)
between September 2009 and May 2015. Survival outcomes and grade 3–4 toxicities were compared between
different IC regimen groups.
Results: In total, 3738 patients were eligible for this study, with 1572 (42.1%), 1085 (29.0%) and 1081 (28.9%)
receiving TPF, PF and TP, respectively. In the whole population, multivariate analysis found that TPF seems to be
better than PF and TP. Howerver, subgroup analysis revealed TPF and TP had same effectiveness in patients
receiving a cumulative cisplatin dose (CCD) ≥ 200 mg/m2 in concurrent chemotherapy, while TPF shows re
latively better survival benefit in patients receiving CCD < 200 mg/m2. Grade 3–4 toxicities were similar be
tween TPF and TP groups, but were relatively higher than that in PF group.
Conclusions: Our study concluded that induction TP regimen may be enough for patients receiving a
CCD ≥ 200 mg/m2, while TPF may be superior to TP and PF for patients receiving a CCD < 200 mg/m2, al
though grade 3–4 toxic events were more common but tolerable. Further studies are needed to validate our
findings.
Keywords: Nasopharyngeal carcinoma ، Induction chemotherapy ، Locoregionally advanced، Intensity-modulated radiotherapy ، Prognosis |
مقاله انگلیسی |
3 |
نانوذرات طلا برای کاربرد پرتودرمانی سرطان: مکانیزیم ها و پیشرفتهای اخیر
سال انتشار: 2017 - تعداد صفحات فایل pdf انگلیسی: 18 - تعداد صفحات فایل doc فارسی: 70 نانوذرات طلا (AuNP) به عنوان داروهای حساس کننده به پرتو استفاده میشوند زیرا جذب بالایی برای اشعههای X، تطبیق پذیری چندمنظوره و خواص منحصر به فرد شیمیایی، الکترونیکی و یونی دارند. پژوهشهای چندرشتهای در دههی گذشته انجام شده و نشان داده است که پتانسیل داروهای حساس کننده به پرتوی مبتنی بر AuNP و مکانیزیمهای شناسایی شدهی ممکن چگونه هستند که بر حسب اثرات افزایش تششعات AuNPها هستند. با وجود اینکه یافتههای امیدوارکنندهای از مطالعات پیش بالینی بدست آمده است، مزایای حساسیت رادیویی AuNP به موفقیت بالینی تفسیر میشود. در این بررسی، مروری از وضعیت فعلی داروهای حساس کننده به پرتوی مبتنی بر AuNP در حالتهای فیزیکی، شیمیایی و بیولوژیکی حساس کننده ارائه کردهایم. همچنین پیشرفتهای اخیر که بر طراحی فرمولاسیون تمرکز کردهاند و امکان کاربردهای بالینی و درمانی چندگانه را فراهم آوردهاند مورد بحث قرار گرفتهاند و با ملاحظات طراحی به نتیجه گیری انجامیدهاند تا باعث توسعهی AuNPهای نسل بعد برای کاربردهای بالینی شوند.
کلمات کلیدی: حساسیت رادیویی | پرتودرمانی | نانوذرات طلا | مکانیزیم | نانوذرات چندمنظوره | داروهای حساس کننده به پرتو هیپوکسیک | هدف گذاری فعال | رادیوتراپی یونی |
مقاله ترجمه شده |
4 |
Improved survival with postoperative radiotherapy in thymic carcinoma: A propensity-matched analysis of Surveillance, Epidemiology, and End Results (SEER) database
بقای بهبود یافته با رادیوتراپی پس از عمل در کارسینوم ایممی: یک تجزیه و تحلیل وابسته به تماسی از پایگاه داده های نظارت، اپیدمیولوژی و پایان (SEER)-2017 Objectives: Thymic carcinoma is a rare and aggressive malignancy with poor prognosis. Although post
operative radiotherapy (PORT) is used for obtaining better locoregional tumor control, its association
with survival has not been established. This study evaluated the prognostic impact of PORT in thymic
carcinoma.
Materials and methods: We identified patients diagnosed with thymic carcinoma between 2004 and 2013
using the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching with
Kaplan-Meier and Cox-regression analyses were used to assess prognosis.
Results: In the unmatched population (n = 312), 184 (59%) patients underwent PORT. The 5-year overall
survival rates were better with receipt of PORT, both before and after matching (P = 0.012 and 0.007,
respectively). After adjusting for related covariates (n = 256), age ≥63 years (P = 0.023), Masaoka stage
III (P = 0.028) and IV (P < 0.001), debulking surgery (P = 0.021), and no receipt of PORT (P = 0.013) were
independently poor prognostic factors. In subgroup analyses, favorable survival impacts of PORT were
observed for Masaoka stage III tumors (hazard ratio [HR] 0.31, 95% confidence interval [CI] 0.15–0.66),
tumors sized >6.0 cm (HR 0.48, 95% CI 0.26–0.89), node-negative status (HR 0.58, 95% CI 0.33–1.00), and
surgical extent of local excision or partial removal (HR 0.44, 95% CI 0.22–0.86).
Conclusion: On SEER analysis, survival benefits of PORT in thymic carcinoma were demonstrated. With
strong prognostic associations of Masaoka stage and types of surgery, PORT should be considered for
non-metastatic locally advanced tumors with limited surgical resection.
Keywords: Thymiccarcinoma | SEER program | Propensity score matching | Postoperative radiotherapy | Overall survival |
مقاله انگلیسی |