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نتیجه جستجو - پپتیدها

تعداد مقالات یافته شده: 10
ردیف عنوان نوع
1 Characterization of the innate immunity in the mud crab Scylla paramamosain
خصوصیات ایمنی ذاتی در خرچنگ گل Scylla paramamosain-2019
Mud crabs, Scylla paramamosain, are one of the most economical and nutritious crab species in China and South Asia. Inconsistent with the high development of commercial mud crab aquaculture, effective immunological methods to prevent frequently-occurring diseases have not yet been developed. Thus, high mortalities often occur throughout the different developmental stages of this species resulting in large economic losses. In recent years, numerous attempts have been made to use various advanced biological technologies to understand the innate immunity of S. paramamosain as well as to characterize specific immune components. This review summarizes these research advances regarding cellular and humoral responses of the mud crab during pathogen infection, highlighting hemocytes and gills defense, pattern recognition, immune-related signaling pathways (Toll, IMD, JAK/STAT, and prophenoloxidase (proPO) cascades), immune effectors (antimicrobial peptides), production of reactive oxygen species and the antioxidant system. Diseases affecting the development of mud crab aquaculture and potential disease control strategies are discussed.
Keywords: Scylla paramamosain | Innate immunity | Pattern recognition | Signaling pathway | Antimicrobial peptides | Antioxidant system
مقاله انگلیسی
2 Role of peptide transporter 2 and MAPK signaling pathways in the innate immune response induced by bacterial peptides in alveolar epithelial cells
نقش حمل و نقل پپتید 2 و مسیرهای سیگنالینگ MAPK در پاسخ ایمنی ذاتی ناشی از پپتیدهای باکتریایی در سلولهای اپیتلیال آلوئول-2019
Aims: The innate immune response induced by bacterial peptidoglycan peptides, such as γ-D-glutamyl-mesodiaminopimelic acid (iE-DAP), is an important host defense system. However, little is known about the innate immune response in the lung alveolar region. In this study, we examined induction of the innate immune response by iE-DAP in human alveolar epithelial cell lines, NCI-H441 (H441) and A549. Main methods: Induction of the innate immune response was evaluated by measuring the mRNA expression of cytokines and their release into the culture medium. Key findings: iE-DAP treatment increased the mRNA expression of interleukin (IL)-6 and IL-8, and increased release of these pro-inflammatory cytokines into the culture medium in H441 cells, but not in A549 cells. Lack of release of these cytokines in A549 cells may have been due to lack of peptide transporter 2 (PEPT2) function. Intracellular nucleotide-binding oligomerization domain 1 (NOD1) recognizes iE-DAP and activates downstream signaling pathways to initiate the immune response. Therefore, the role of mitogen-activated protein kinase (MAPK) signaling pathways was examined in H441 cells. As a result of inhibition studies, receptor-interacting serine/threonine-protein kinase 2 and MAPK signaling pathways, such as p38 MAPK and extracellular signalregulated kinase, but not c-Jun N-terminal kinase, were determined to be involved in the innate immune response in H441 cells. In addition, the nuclear factor κB pathway also played a role in the innate immune response. Significance: These findings indicated that the innate immune response induced by bacterial peptides could occur in a PEPT2- and NOD1-dependent manner in alveolar epithelial cells.
Keywords: Alveolar epithelial cells | Bacterial peptides | Innate immune response| Mitogen-activated protein kinase | Pattern recognition receptor | Peptide transporter 2
مقاله انگلیسی
3 Peptidoglycan recognition proteins in insect immunity
پروتئین های تشخیص پپتیدوگلیکان در مصونیت حشرات-2019
Insects lack an acquired immune system and rely solely on the innate immune system to combat microbial infection. The innate immunity of insects mainly depends on the interaction between the hosts pattern recognition receptor (PRR) and pathogen-associated molecular pattern (PAMP). The peptidoglycan recognition proteins (PGRPs) family is the most important pattern recognition receptor (PRR) for insects. It can recognize the main component of the cell wall of the pathogenic microorganism, peptidoglycan (PGN), and plays an important role in the innate immunity of insects. In this paper, the structure, classification, and function of PGRPs is summarized, and the role of PGRPs in the innate immunity of insects is also discussed.
Keywords: The peptidoglycan recognition proteins | Innate immune | Toll, IMD and PPO pathway | Antimicrobial peptides
مقاله انگلیسی
4 Renal function, N-terminal Pro-B-Type natriuretic peptide, propeptide big endothelin and patients with heart failure and preserved ejection fraction
عملکرد کلیوی، N ترمینال نرم افزار-B پپتید ناتریورتیک، propeptide اندوتلین بزرگ و بیماران مبتلا به نارسایی قلب و کسر خروجی حفظ-2018
Renal dysfunction may limit the clinical application of NT-proBNP in the diagnosis of heart failure. In general practice, where echocardiography is not readily available, a biomarker for the diagnosis of a heart failure with preserved ejection fraction (HFpEF) would be useful. Since cardiac diseases frequently coincide with renal disease, there is a high need of valid risk stratification methods in patients affected with both. We therefore examined NT-proBNP and another biomarker, Big-Endothelin-1, as a marker of HFpEF in patients with CKD. NT-proBNP and Big-ET-1 were determined in 439 patients with HFpEF in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. NT-proBNP plasma level has shown an exponential increase with declining GFR, while Big-ET-1 plasma level increased only in a moderate and linear fashion. In patients without CKD, a NT-proBNP cut-off point at 250 pg/ mL was suitable for the discrimination between HFpEF and patients without HF. When the GFR was less than 60 mL/min/1.73m2, the NT-proBNP cut-off point should be raised to 750 pg/mL. At a cutoff point at 0.85 fmol/ L, Big-ET-1 allowed to distinguish patients with HFpEF from persons without HF, independently of GFR. In general, NT-proBNP is a good indicator of suspected heart failure. While for NT-proBNP different cut-off points have to be considered in the diagnosis of HFpEF, a single cut-off point of Big-ET-1 was appropriate in the diagnosis of HFpEF, regardless of the presence or absence of CKD. An additional measurement of Big-ET-1 improves the diagnosis of HFpEF in patients with chronic kidney disease.
Keywords: N-Terminal Pro-B-Type natriuretic peptide ، (NT-proBNP)، Big-Endothelin-1 (Big-ET-1) ، Heart failure with preserved ejection fraction ، (HFpEF) ، Chronic kidney disease (CKD) ، Peptides ، Biomarkers
مقاله انگلیسی
5 Small molecule mimics of DFTamP1, a database designed anti-Staphylococcal peptide
تقلید مولکول کوچک از DFTamP1، یک پپتید ضد استافیلوکوکی پایگاه داده طراحی شده-2017
Antimicrobial peptides (AMPs) are important templates for developing new antimicrobial agents. Previously, we developed a database filtering technology that enabled us to design a potent anti Staphylococcal peptide DFTamP1. Using this same design approach, we now report the discovery of a new class of bis-indole diimidazolines as AMP small molecule mimics. The best compound killed multiple S. aureus clinical strains in both planktonic and biofilm forms. The compound appeared to target bacterial membranes with antimicrobial activity and membrane permeation ability similar to daptomycin.
Keywords: Antimicrobial peptides | Chemical synthesis | Database filtering technology | Peptide mimics
مقاله انگلیسی
6 Building parity between brand and generic peptide products: Regulatory and scientific considerations for quality of synthetic peptides
همبستگی بین نام تجاری و محصولات پپتید عمومی: ملاحظات نظارتی و علمی برای کیفیت پپتیدهای مصنوعی-2017
Peptides are a fast growing segment in the pharmaceutical industry. Consequently, the industry and regulatory agencies are increasing their focus on the regulatory path and quality considerations for peptide development and manufacturing. Although most peptides are synthetic, manufactured by solid phase synthesis, nevertheless they are complex molecules with challenging quality and regulatory aspects. This paper provides a structured overview of relevant quality issues for chemically synthesized peptides used as active pharmaceutical ingredients (API) in drug products. It addresses the unique characteristics of peptides pertaining to structural and physicochemical characterization, manufacturing and in process controls, impurities and aggregates arising from manufacturing and storage, along with their potential impact on safety (including immunogenicity) and efficacy of the peptide drug products.
Keywords: Peptide | Regulatory | Risk assessment | Quality control | Peptide structure | Solid phase peptide synthesis
مقاله انگلیسی
7 InverPep: A database of invertebrate antimicrobial peptides
InverPep: پایگاه داده ای از پپتیدهای ضد میکروبی بی مهره-2017
Objectives: The aim of this work was to construct InverPep, a database specialised in experimentally validated antimicrobial peptides (AMPs) from invertebrates. Methods: AMP data contained in InverPep were manually curated from other databases and the scientific literature. MySQL was integrated with the development platform Laravel; this framework allows to integrate programming in PHP with HTML and was used to design the InverPep web page’s interface. InverPep contains 18 separated fields, including InverPep code, phylum and species source, peptide name, sequence, peptide length, secondary structure, molar mass, charge, isoelectric point, hydrophobicity, Boman index, aliphatic index and percentage of hydrophobic amino acids. CALCAMPI, an algorithm to calculate the physicochemical properties of multiple peptides simultaneously, was programmed in PERL language. Results: To date, InverPep contains 702 experimentally validated AMPs from invertebrate species. All of the peptides contain information associated with their source, physicochemical properties, secondary structure, biological activity and links to external literature. Most AMPs in InverPep have a length between 10 and 50 amino acids, a positive charge, a Boman index between 0 and 2 kcal/mol, and 30–50% hydrophobic amino acids. InverPep includes 33 AMPs not reported in other databases. Besides, CALCAMPI and statistical analysis of InverPep data is presented. The InverPep database is available in English and Spanish. Conclusions: InverPep is a useful database to study invertebrate AMPs and its information could be used for the design of new peptides. The user-friendly interface of InverPep and its information can be freely accessed via a web-based browser at http://ciencias.medellin.unal.edu.co/gruposdeinvestigacion/ prospeccionydisenobiomoleculas/InverPep/public/home_en.
Keywords: Invertebrate | Antimicrobial peptide | Web database | Bioinformatics
مقاله انگلیسی
8 Computational design of peptide ligands to target the intermolecular interaction between viral envelope protein and pediatric receptor
طراحی محاسباتی از لیگاندهای پپتیدی برای هدف قرار دادن تعامل بین مولکولی پروتئین پاکت های ویروسی و گیرنده های اطفال-2017
The recognition and binding of viral envelope protein to pediatric receptor subverts the membrane trafficking apparatus to mediate virion export in young children. Here, we described a successful computational design of peptide ligands to target the intermolecular interaction between the virus large envelope protein (LHB) and adaptin receptor (ADT). Based on the crystal structure of ADT in complex with an oligopeptide segment corresponding to the core binding site of LHB, a sequence-specific amino acid preference profile was determined systematically for the ADT-binding peptides using structural bioinformatics approach. With the information harvested from the profile, a genetic evolution procedure was run to improve the biological potency of a peptide population generated randomly from the LHB. A number of potential hits were obtained from the evolution, and four were measured to interact with ADT at micromolar level. A high-affinity hit peptide was then optimized according to computational structural analysis. It is revealed that a potent peptide can be divided into three regions, i.e. a negatively charged region at N-terminus, a hydrophobic core region in middle, and a small, polar region at C terminal tail. In addition, the two termini of peptide are partially out of the active pocket of ADT, thus contributing moderately to the peptide binding.
Keywords: Virus large envelope protein | Rational peptide design | Structural bioinformatics | Pediatric receptor
مقاله انگلیسی
9 Oxytocin and vasopressin neural networks: Implications for social behavioral diversity and translational neuroscience
شبکه های عصبی اکسي توسين و وازوپرسین : پيامدهای تنوع رفتاری اجتماعی و تحقيقات علوم اعصاب-2017
Oxytocin- and vasopressin-related systems are present in invertebrate and vertebrate bilaterian animals, including humans, and exhibit conserved neuroanatomical and functional properties. In vertebrates, these systems innervate conserved neural networks that regulate social learning and behavior, including conspecific recognition, social attachment, and parental behavior. Individual and species-level variation in central organization of oxytocin and vasopressin systems has been linked to individual and species vari ation in social learning and behavior. In humans, genetic polymorphisms in the genes encoding oxytocin and vasopressin peptides and/or their respective target receptors have been associated with individual variation in social recognition, social attachment phenotypes, parental behavior, and psychiatric phe notypes such as autism. Here we describe both conserved and variable features of central oxytocin and vasopressin systems in the context of social behavioral diversity, with a particular focus on neural net works that modulate social learning, behavior, and salience of sociosensory stimuli during species-typical social contexts.
Keywords: Social behavior network | Social decision-making network | Salience | Valence | Social behavior | Social cognition | Neuropeptides | Functional connectivity | Functional coupling | Autism spectrum disorders | Social attachment | Pair bonding | Oxtr | Avpr1a
مقاله انگلیسی
10 کونژوگه کردن دی پپتید فلورسنت خودمونتاژ برای نشان دار کردن سلولی
سال انتشار: 2016 - تعداد صفحات فایل pdf انگلیسی: 5 - تعداد صفحات فایل doc فارسی: 14
مشتقات فلوروفور FITC(ایزوتیوسیانات فلورسین) به طور گسترده ای در روش های زیستی برای نشان دار کردن پروتئین ها و سلول ها به کار رفته است.دی پپتید لوسین N-terminal به FITC متصل شده است و ما نشان دادیم که این مولکول ساده سازگار با سلول است و در مقایسه با FITC توسط سلول ها(پوست انسان و فیبروبلاست قرنیه) جذب شده است.همسان سازی موقعیت نشان داده است که FITC-LL در قسمت های ویزیکولی داخل سلولی و اطراف هسته جداسازی می شود.در بالای غلظت تراکمی بحرانی،کونژوگه نشان داده است که به نانوساختار های ورقه ای بتا که شامل دولایه های مولکولی است،خودمونتاژ می شود.
کلمات کلیدی: پپتیدهای | ترکیبات پپتید | خود مونتاژ | فلورسنس
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