با سلام خدمت کاربران در صورتی که با خطای سیستم پرداخت بانکی مواجه شدید از طریق کارت به کارت (6037997535328901 بانک ملی ناصر خنجری ) مقاله خود را دریافت کنید (تا مشکل رفع گردد).
ردیف | عنوان | نوع |
---|---|---|
1 |
Characterization of the innate immunity in the mud crab Scylla paramamosain
خصوصیات ایمنی ذاتی در خرچنگ گل Scylla paramamosain-2019 Mud crabs, Scylla paramamosain, are one of the most economical and nutritious crab species in China and South
Asia. Inconsistent with the high development of commercial mud crab aquaculture, effective immunological
methods to prevent frequently-occurring diseases have not yet been developed. Thus, high mortalities often
occur throughout the different developmental stages of this species resulting in large economic losses. In recent
years, numerous attempts have been made to use various advanced biological technologies to understand the
innate immunity of S. paramamosain as well as to characterize specific immune components. This review
summarizes these research advances regarding cellular and humoral responses of the mud crab during pathogen
infection, highlighting hemocytes and gills defense, pattern recognition, immune-related signaling pathways
(Toll, IMD, JAK/STAT, and prophenoloxidase (proPO) cascades), immune effectors (antimicrobial peptides),
production of reactive oxygen species and the antioxidant system. Diseases affecting the development of mud
crab aquaculture and potential disease control strategies are discussed. Keywords: Scylla paramamosain | Innate immunity | Pattern recognition | Signaling pathway | Antimicrobial peptides | Antioxidant system |
مقاله انگلیسی |
2 |
Role of peptide transporter 2 and MAPK signaling pathways in the innate immune response induced by bacterial peptides in alveolar epithelial cells
نقش حمل و نقل پپتید 2 و مسیرهای سیگنالینگ MAPK در پاسخ ایمنی ذاتی ناشی از پپتیدهای باکتریایی در سلولهای اپیتلیال آلوئول-2019 Aims: The innate immune response induced by bacterial peptidoglycan peptides, such as γ-D-glutamyl-mesodiaminopimelic
acid (iE-DAP), is an important host defense system. However, little is known about the innate
immune response in the lung alveolar region. In this study, we examined induction of the innate immune response
by iE-DAP in human alveolar epithelial cell lines, NCI-H441 (H441) and A549.
Main methods: Induction of the innate immune response was evaluated by measuring the mRNA expression of
cytokines and their release into the culture medium.
Key findings: iE-DAP treatment increased the mRNA expression of interleukin (IL)-6 and IL-8, and increased
release of these pro-inflammatory cytokines into the culture medium in H441 cells, but not in A549 cells. Lack of
release of these cytokines in A549 cells may have been due to lack of peptide transporter 2 (PEPT2) function.
Intracellular nucleotide-binding oligomerization domain 1 (NOD1) recognizes iE-DAP and activates downstream
signaling pathways to initiate the immune response. Therefore, the role of mitogen-activated protein kinase
(MAPK) signaling pathways was examined in H441 cells. As a result of inhibition studies, receptor-interacting
serine/threonine-protein kinase 2 and MAPK signaling pathways, such as p38 MAPK and extracellular signalregulated
kinase, but not c-Jun N-terminal kinase, were determined to be involved in the innate immune response
in H441 cells. In addition, the nuclear factor κB pathway also played a role in the innate immune response.
Significance: These findings indicated that the innate immune response induced by bacterial peptides could
occur in a PEPT2- and NOD1-dependent manner in alveolar epithelial cells. Keywords: Alveolar epithelial cells | Bacterial peptides | Innate immune response| Mitogen-activated protein kinase | Pattern recognition receptor | Peptide transporter 2 |
مقاله انگلیسی |
3 |
Peptidoglycan recognition proteins in insect immunity
پروتئین های تشخیص پپتیدوگلیکان در مصونیت حشرات-2019 Insects lack an acquired immune system and rely solely on the innate immune system to combat microbial
infection. The innate immunity of insects mainly depends on the interaction between the hosts pattern recognition
receptor (PRR) and pathogen-associated molecular pattern (PAMP). The peptidoglycan recognition
proteins (PGRPs) family is the most important pattern recognition receptor (PRR) for insects. It can recognize the
main component of the cell wall of the pathogenic microorganism, peptidoglycan (PGN), and plays an important
role in the innate immunity of insects. In this paper, the structure, classification, and function of PGRPs is
summarized, and the role of PGRPs in the innate immunity of insects is also discussed. Keywords: The peptidoglycan recognition proteins | Innate immune | Toll, IMD and PPO pathway | Antimicrobial peptides |
مقاله انگلیسی |
4 |
Renal function, N-terminal Pro-B-Type natriuretic peptide, propeptide big endothelin and patients with heart failure and preserved ejection fraction
عملکرد کلیوی، N ترمینال نرم افزار-B پپتید ناتریورتیک، propeptide اندوتلین بزرگ و بیماران مبتلا به نارسایی قلب و کسر خروجی حفظ-2018 Renal dysfunction may limit the clinical application of NT-proBNP in the diagnosis of heart failure. In general
practice, where echocardiography is not readily available, a biomarker for the diagnosis of a heart failure with
preserved ejection fraction (HFpEF) would be useful. Since cardiac diseases frequently coincide with renal
disease, there is a high need of valid risk stratification methods in patients affected with both. We therefore
examined NT-proBNP and another biomarker, Big-Endothelin-1, as a marker of HFpEF in patients with CKD.
NT-proBNP and Big-ET-1 were determined in 439 patients with HFpEF in the Ludwigshafen Risk and
Cardiovascular Health (LURIC) study.
NT-proBNP plasma level has shown an exponential increase with declining GFR, while Big-ET-1 plasma level
increased only in a moderate and linear fashion. In patients without CKD, a NT-proBNP cut-off point at 250 pg/
mL was suitable for the discrimination between HFpEF and patients without HF. When the GFR was less than
60 mL/min/1.73m2, the NT-proBNP cut-off point should be raised to 750 pg/mL. At a cutoff point at 0.85 fmol/
L, Big-ET-1 allowed to distinguish patients with HFpEF from persons without HF, independently of GFR.
In general, NT-proBNP is a good indicator of suspected heart failure. While for NT-proBNP different cut-off
points have to be considered in the diagnosis of HFpEF, a single cut-off point of Big-ET-1 was appropriate in the
diagnosis of HFpEF, regardless of the presence or absence of CKD.
An additional measurement of Big-ET-1 improves the diagnosis of HFpEF in patients with chronic kidney
disease.
Keywords: N-Terminal Pro-B-Type natriuretic peptide ، (NT-proBNP)، Big-Endothelin-1 (Big-ET-1) ، Heart failure with preserved ejection fraction ، (HFpEF) ، Chronic kidney disease (CKD) ، Peptides ، Biomarkers |
مقاله انگلیسی |
5 |
Small molecule mimics of DFTamP1, a database designed anti-Staphylococcal peptide
تقلید مولکول کوچک از DFTamP1، یک پپتید ضد استافیلوکوکی پایگاه داده طراحی شده-2017 Antimicrobial peptides (AMPs) are important templates for developing new antimicrobial agents.
Previously, we developed a database filtering technology that enabled us to design a potent anti
Staphylococcal peptide DFTamP1. Using this same design approach, we now report the discovery of a
new class of bis-indole diimidazolines as AMP small molecule mimics. The best compound killed multiple
S. aureus clinical strains in both planktonic and biofilm forms. The compound appeared to target bacterial
membranes with antimicrobial activity and membrane permeation ability similar to daptomycin.
Keywords: Antimicrobial peptides | Chemical synthesis | Database filtering technology | Peptide mimics |
مقاله انگلیسی |
6 |
Building parity between brand and generic peptide products: Regulatory and scientific considerations for quality of synthetic peptides
همبستگی بین نام تجاری و محصولات پپتید عمومی: ملاحظات نظارتی و علمی برای کیفیت پپتیدهای مصنوعی-2017 Peptides are a fast growing segment in the pharmaceutical industry. Consequently, the industry and
regulatory agencies are increasing their focus on the regulatory path and quality considerations for
peptide development and manufacturing. Although most peptides are synthetic, manufactured by solid
phase synthesis, nevertheless they are complex molecules with challenging quality and regulatory
aspects. This paper provides a structured overview of relevant quality issues for chemically synthesized
peptides used as active pharmaceutical ingredients (API) in drug products. It addresses the unique
characteristics of peptides pertaining to structural and physicochemical characterization, manufacturing
and in process controls, impurities and aggregates arising from manufacturing and storage, along with
their potential impact on safety (including immunogenicity) and efficacy of the peptide drug products.
Keywords: Peptide | Regulatory | Risk assessment | Quality control | Peptide structure | Solid phase peptide synthesis |
مقاله انگلیسی |
7 |
InverPep: A database of invertebrate antimicrobial peptides
InverPep: پایگاه داده ای از پپتیدهای ضد میکروبی بی مهره-2017 Objectives: The aim of this work was to construct InverPep, a database specialised in experimentally
validated antimicrobial peptides (AMPs) from invertebrates.
Methods: AMP data contained in InverPep were manually curated from other databases and the scientific
literature. MySQL was integrated with the development platform Laravel; this framework allows to
integrate programming in PHP with HTML and was used to design the InverPep web page’s interface.
InverPep contains 18 separated fields, including InverPep code, phylum and species source, peptide
name, sequence, peptide length, secondary structure, molar mass, charge, isoelectric point,
hydrophobicity, Boman index, aliphatic index and percentage of hydrophobic amino acids. CALCAMPI,
an algorithm to calculate the physicochemical properties of multiple peptides simultaneously, was
programmed in PERL language.
Results: To date, InverPep contains 702 experimentally validated AMPs from invertebrate species. All of
the peptides contain information associated with their source, physicochemical properties, secondary
structure, biological activity and links to external literature. Most AMPs in InverPep have a length
between 10 and 50 amino acids, a positive charge, a Boman index between 0 and 2 kcal/mol, and 30–50%
hydrophobic amino acids. InverPep includes 33 AMPs not reported in other databases. Besides,
CALCAMPI and statistical analysis of InverPep data is presented. The InverPep database is available in
English and Spanish.
Conclusions: InverPep is a useful database to study invertebrate AMPs and its information could be used
for the design of new peptides. The user-friendly interface of InverPep and its information can be freely
accessed via a web-based browser at http://ciencias.medellin.unal.edu.co/gruposdeinvestigacion/
prospeccionydisenobiomoleculas/InverPep/public/home_en.
Keywords: Invertebrate | Antimicrobial peptide | Web database | Bioinformatics |
مقاله انگلیسی |
8 |
Computational design of peptide ligands to target the intermolecular interaction between viral envelope protein and pediatric receptor
طراحی محاسباتی از لیگاندهای پپتیدی برای هدف قرار دادن تعامل بین مولکولی پروتئین پاکت های ویروسی و گیرنده های اطفال-2017 The recognition and binding of viral envelope protein to pediatric receptor subverts the membrane
trafficking apparatus to mediate virion export in young children. Here, we described a successful
computational design of peptide ligands to target the intermolecular interaction between the virus large
envelope protein (LHB) and adaptin receptor (ADT). Based on the crystal structure of ADT in complex with
an oligopeptide segment corresponding to the core binding site of LHB, a sequence-specific amino acid
preference profile was determined systematically for the ADT-binding peptides using structural
bioinformatics approach. With the information harvested from the profile, a genetic evolution procedure
was run to improve the biological potency of a peptide population generated randomly from the LHB. A
number of potential hits were obtained from the evolution, and four were measured to interact with ADT
at micromolar level. A high-affinity hit peptide was then optimized according to computational
structural analysis. It is revealed that a potent peptide can be divided into three regions, i.e. a negatively
charged region at N-terminus, a hydrophobic core region in middle, and a small, polar region at C
terminal tail. In addition, the two termini of peptide are partially out of the active pocket of ADT, thus
contributing moderately to the peptide binding.
Keywords: Virus large envelope protein | Rational peptide design | Structural bioinformatics | Pediatric receptor |
مقاله انگلیسی |
9 |
Oxytocin and vasopressin neural networks: Implications for social behavioral diversity and translational neuroscience
شبکه های عصبی اکسي توسين و وازوپرسین : پيامدهای تنوع رفتاری اجتماعی و تحقيقات علوم اعصاب-2017 Oxytocin- and vasopressin-related systems are present in invertebrate and vertebrate bilaterian animals,
including humans, and exhibit conserved neuroanatomical and functional properties. In vertebrates,
these systems innervate conserved neural networks that regulate social learning and behavior, including
conspecific recognition, social attachment, and parental behavior. Individual and species-level variation
in central organization of oxytocin and vasopressin systems has been linked to individual and species vari
ation in social learning and behavior. In humans, genetic polymorphisms in the genes encoding oxytocin
and vasopressin peptides and/or their respective target receptors have been associated with individual
variation in social recognition, social attachment phenotypes, parental behavior, and psychiatric phe
notypes such as autism. Here we describe both conserved and variable features of central oxytocin and
vasopressin systems in the context of social behavioral diversity, with a particular focus on neural net
works that modulate social learning, behavior, and salience of sociosensory stimuli during species-typical
social contexts.
Keywords: Social behavior network | Social decision-making network | Salience | Valence | Social behavior | Social cognition | Neuropeptides | Functional connectivity | Functional coupling | Autism spectrum disorders | Social attachment | Pair bonding | Oxtr | Avpr1a |
مقاله انگلیسی |
10 |
کونژوگه کردن دی پپتید فلورسنت خودمونتاژ برای نشان دار کردن سلولی
سال انتشار: 2016 - تعداد صفحات فایل pdf انگلیسی: 5 - تعداد صفحات فایل doc فارسی: 14 مشتقات فلوروفور FITC(ایزوتیوسیانات فلورسین) به طور گسترده ای در روش های زیستی برای نشان دار کردن پروتئین ها و سلول ها به کار رفته است.دی پپتید لوسین N-terminal به FITC متصل شده است و ما نشان دادیم که این مولکول ساده سازگار با سلول است و در مقایسه با FITC توسط سلول ها(پوست انسان و فیبروبلاست قرنیه) جذب شده است.همسان سازی موقعیت نشان داده است که FITC-LL در قسمت های ویزیکولی داخل سلولی و اطراف هسته جداسازی می شود.در بالای غلظت تراکمی بحرانی،کونژوگه نشان داده است که به نانوساختار های ورقه ای بتا که شامل دولایه های مولکولی است،خودمونتاژ می شود.
کلمات کلیدی: پپتیدهای | ترکیبات پپتید | خود مونتاژ | فلورسنس |
مقاله ترجمه شده |