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نتیجه جستجو - یادگیری رمزگذار ویژگی های انعطاف پذیر

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1 When machine vision meets histology: A comparative evaluation of model architecture for classification of histology sections
هنگامی که بینایی دستگاه با بافت شناسی مقابله می شود: ارزیابی مقایسه ای از معماری مدل برای طبقه بندی بخش های بافت شناسی-2017
Article history:Received 25 February 2016Revised 12 August 2016Accepted 26 August 2016Available online 9 September 2016Keywords:Computational histopathology ClassificationUnsupervised feature learning Sparse feature encoderClassification of histology sections in large cohorts, in terms of distinct regions of microanatomy (e.g., stromal) and histopathology (e.g., tumor, necrosis), enables the quantification of tumor composition, and the construction of predictive models of genomics and clinical outcome. To tackle the large technical vari- ations and biological heterogeneities, which are intrinsic in large cohorts, emerging systems utilize either prior knowledge from pathologists or unsupervised feature learning for invariant representation of the underlying properties in the data. However, to a large degree, the architecture for tissue histology classi- fication remains unexplored and requires urgent systematical investigation. This paper is the first attempt to provide insights into three fundamental questions in tissue histology classification: I. Is unsupervised feature learning preferable to human engineered features? II. Does cellular saliency help? III. Does the sparse feature encoder contribute to recognition? We show that (a) in I, both Cellular Morphometric Fea- ture and features from unsupervised feature learning lead to superior performance when compared to SIFT and [Color, Texture]; (b) in II, cellular saliency incorporation impairs the performance for systems built upon pixel-/patch-level features; and (c) in III, the effect of the sparse feature encoder is correlated with the robustness of features, and the performance can be consistently improved by the multi-stage ex- tension of systems built upon both Cellular Morphmetric Feature and features from unsupervised feature learning. These insights are validated with two cohorts of Glioblastoma Multiforme (GBM) and Kidney Clear Cell Carcinoma (KIRC).© 2016 Elsevier B.V. All rights reserved.
Keywords: Computational histopathology | Classification | Unsupervised feature learning | Sparse feature encoder
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